Gender-specific differences in the association of HDL and HDL-related oxidative stress indicators with the occurrence of major depressive disorder and bipolar disorder: A large-scale study

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders Pub Date : 2025-05-29 DOI:10.1016/j.jad.2025.119530

Yanyan Wei , Chenjiao Zhang , Bo Sun , Jingyu Lin , Yanli Zhao , Yujie Chen , Huanqin Gao , Jinhao Li , Guoguang Li , Junhui Feng , Jinbao Ma , Jingxu Chen

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引用次数: 0

Abstract

Objective

Numerous studies have demonstrated that High-Density Lipoprotein (HDL) has antioxidant and anti-inflammatory roles. Uric acid to HDL ratio (UHR), non-HDL cholesterol to HDL ratio (NHHR), monocyte to HDL ratio (MHR), neutrophil to HDL ratio (NHR), total cholesterol to HDL ratio (TCHR), triglyceride to HDL ratio (TGHR) can serve as inflammation and oxidative stress markers in multiple diseases. However, few studies have estimated the associations of these indicators with major depressive disorder (MDD) and bipolar disorder (BD) in different genders.

Methods

Based on 14,266 patients with MDD or BD and 8308 healthy subjects from China, we analyzed the associations between these indicators and diseases as well as gender.

Results

8201 MDD patients, 4069 patients with BD manic episodes (BDM) and 1996 patients with BD depressive episodes (BDD) were included. The HDL-related indicators displayed unique variation patterns across different disease groups and genders. In males, the BDM group displayed highest NHR, MHR, UHR and lowest NHHR and TCHR, lower UHR and NHHR were risk factors of MDD, lower NHHR was risk factors of BDD, higher MHR and lower NHHR were risk factors of BDM. In females, the BDM group displayed highest NHR, MHR and UHR, higher TGHR was risk factor of MDD, higher MHR, TGHR and UHR were risk factors of BDD, higher NHR, MHR, TGHR and UHR were risk factors of BDM.

Conclusions

Gender-specific differences in HDL-related profile among BDM, BDD and MDD patients were demonstrated, highlighting gender-specific role of HDL-related indicators in the pathophysiology of MDD and BD.

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高密度脂蛋白和高密度脂蛋白相关氧化应激指标与重度抑郁症和双相情感障碍发生的性别差异：一项大规模研究

目的：大量研究表明高密度脂蛋白（HDL）具有抗氧化和抗炎作用。尿酸与高密度脂蛋白比值（UHR）、非高密度脂蛋白胆固醇与高密度脂蛋白比值（NHHR）、单核细胞与高密度脂蛋白比值（MHR）、中性粒细胞与高密度脂蛋白比值（NHR）、总胆固醇与高密度脂蛋白比值（TCHR）、甘油三酯与高密度脂蛋白比值（TGHR）可作为多种疾病的炎症和氧化应激标志物。然而，很少有研究估计这些指标与不同性别的重度抑郁症（MDD）和双相情感障碍（BD）的关联。方法：选取14266例重度抑郁或双相障碍患者和8308名健康人群，分析这些指标与疾病及性别的相关性。结果：共纳入8201例重度抑郁症患者，4069例双相躁狂发作（BDM）患者和1996例双相抑郁发作（BDD）患者。高密度脂蛋白相关指标在不同疾病组和性别之间表现出独特的变化模式。男性BDM组NHR、MHR、UHR最高，NHHR和TCHR最低，较低的UHR和NHHR是MDD的危险因素，较低的NHHR是BDD的危险因素，较高的MHR和较低的NHHR是BDM的危险因素。女性BDM组NHR、MHR和UHR最高，较高的TGHR是MDD的危险因素，较高的MHR、TGHR和UHR是BDD的危险因素，较高的NHR、MHR、TGHR和UHR是BDM的危险因素。结论：BDM、BDD和MDD患者的hdl相关特征存在性别差异，突出了hdl相关指标在MDD和BD病理生理中的性别特异性作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of affective disorders 医学-精神病学

CiteScore

10.90

自引率

6.10%

发文量

1319

审稿时长

9.3 weeks

期刊介绍： The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.