Ultrasound Combined With FNA-Tg Predicts the Lateral Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma

IF 1 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Diagnostic Cytopathology Pub Date : 2025-05-31 DOI:10.1002/dc.25489

Yan Liu, Ling Xiang, Yi Wang, Noorazrul Azmie Yahya, Jing-kun Yin, Wei Li, Hamzaini Bin Abdul Hamid, Jia-ning Chai, Hanani Abdul Manan

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引用次数: 0

Abstract

Objective

The present study analyzed typical ultrasound manifestations and fine-needle aspiration thyroglobulin (FNA-Tg) levels to investigate their association with cervical lymph node metastasis in patients with papillary thyroid carcinoma (PTC).

Methods

The data of 139 PTC patients with ultrasonically suspected cervical lymph node metastasis treated in our hospital from December 2022 to November 2023 were retrospectively analyzed. All included patients underwent ultrasound examination of cervical lymph nodes, fine needle aspiration cytology (FNA-C) examination, and ultrasound-guided lymph node aspiration eluent thyroglobulin (FNA-Tg). Typical ultrasound signs for diagnosing cervical lymph node metastasis (US-M) and ultrasound-guided FNA-Tg for diagnosing cervical lymph node metastasis were compared and analyzed.

Results

Results indicate that 71 patients were diagnosed with cervical lymph node metastasis through surgery and subsequently included in the metastatic group; the remaining 68 patients were included in the nonmetastatic group. The FNA-Tg value in the metastatic group was higher than that in the nonmetastatic group; the difference was significant (p < 0.001). The AUC values for diagnosing cervical lymph node metastasis in PTC patients using US-M, FNA-Tg, and US-M+FNA-Tg were 0.854, 0.927, and 0.952. When the cut-off value of FNA-Tg was 229.1 ng/mL, the sensitivity and specificity for diagnosing cervical lymph node metastasis in PTC patients were 84.5% and 89.5%.

Conclusions

Ultrasound-guided FNA-Tg level is closely related to cervical lymph node metastasis in patients with PTC. The combination of ultrasound examination and FNA-Tg testing significantly enhances the accuracy of predicting lateral cervical lymph node metastasis in patients with PTC.

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超声联合FNA-Tg预测甲状腺乳头状癌颈侧淋巴结转移。

目的：分析甲状腺乳头状癌（PTC）患者的典型超声表现及细针穿刺甲状腺球蛋白（FNA-Tg）水平，探讨其与颈部淋巴结转移的关系。方法：回顾性分析我院2022年12月至2023年11月收治的139例超声怀疑颈淋巴转移的PTC患者的资料。所有患者均行宫颈淋巴结超声检查、细针吸细胞学检查（FNA-C）和超声引导淋巴结吸甲状腺球蛋白洗脱液（FNA-Tg）检查。比较分析超声诊断颈淋巴转移的典型征象（US-M）与超声引导下FNA-Tg诊断颈淋巴转移的差异。结果：71例患者经手术诊断为颈部淋巴结转移，并纳入转移组；其余68例患者被纳入非转移组。转移组FNA-Tg值高于非转移组；结论：超声引导下FNA-Tg水平与PTC患者颈部淋巴结转移密切相关。超声检查结合FNA-Tg检测可显著提高预测PTC患者颈侧淋巴结转移的准确性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diagnostic Cytopathology 医学-病理学

CiteScore

2.60

自引率

7.70%

发文量

163

审稿时长

3-6 weeks

期刊介绍： Diagnostic Cytopathology is intended to provide a forum for the exchange of information in the field of cytopathology, with special emphasis on the practical, clinical aspects of the discipline. The editors invite original scientific articles, as well as special review articles, feature articles, and letters to the editor, from laboratory professionals engaged in the practice of cytopathology. Manuscripts are accepted for publication on the basis of scientific merit, practical significance, and suitability for publication in a journal dedicated to this discipline. Original articles can be considered only with the understanding that they have never been published before and that they have not been submitted for simultaneous review to another publication.