{"title":"Secondary Hypertension in Children-Identifying and Investigating at Risk Children.","authors":"Fang Chao Linda Ding, Blake J Sandery","doi":"10.1007/s11906-025-01333-8","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose of review: </strong>We aim to review the most recent literature on demographic features and diagnostic workup of children with secondary hypertension, in order to provide a framework for health providers to determine which hypertensive pediatric patients warrant further investigation for secondary causes. By highlighting the utility of various diagnostic investigations, we aim to minimize unnecessary testing burden.</p><p><strong>Recent findings: </strong>A recent meta-analysis revealed that hypertensive children and adolescents with any of the following features were at increased risk of secondary hypertension: < 6 years of age, history of prematurity, family history of secondary hypertension, body mass index (BMI) < 10th percentile. Based on available evidence, we suggest a testing schema that is stratified by both age and BMI. Limited evidence suggest renal ultrasound may be one of the most useful initial investigations for secondary causes in asymptomatic hypertensive children. Lipid profile in overweight/obese children, and echocardiogram for end organ involvement may have high yield of abnormal results. Further studies on the diagnostic utility of tests for secondary hypertension are required, as the current body of evidence is limited.</p>","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":"27 1","pages":"16"},"PeriodicalIF":3.9000,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Hypertension Reports","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11906-025-01333-8","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose of review: We aim to review the most recent literature on demographic features and diagnostic workup of children with secondary hypertension, in order to provide a framework for health providers to determine which hypertensive pediatric patients warrant further investigation for secondary causes. By highlighting the utility of various diagnostic investigations, we aim to minimize unnecessary testing burden.
Recent findings: A recent meta-analysis revealed that hypertensive children and adolescents with any of the following features were at increased risk of secondary hypertension: < 6 years of age, history of prematurity, family history of secondary hypertension, body mass index (BMI) < 10th percentile. Based on available evidence, we suggest a testing schema that is stratified by both age and BMI. Limited evidence suggest renal ultrasound may be one of the most useful initial investigations for secondary causes in asymptomatic hypertensive children. Lipid profile in overweight/obese children, and echocardiogram for end organ involvement may have high yield of abnormal results. Further studies on the diagnostic utility of tests for secondary hypertension are required, as the current body of evidence is limited.
期刊介绍:
This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of hypertension.
We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as antihypertensive therapies, associated metabolic disorders, and therapeutic trials. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.