Alternative Combinations of IL17A Polymorphic Variants with the Variants of TNF, IL1B, IL6, and IL8 Proinflammatory Cytokines Genes in Uterine Leiomyoma.

IF 0.6 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2025-04-01 Epub Date: 2025-05-31 DOI:10.1007/s10517-025-06412-z

V I Konenkov, V F Prokofiev, A V Shevchenko, E G Koroleva, Yu S Timofeeva, S V Aidagulova, I O Marinkin

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引用次数: 0

Abstract

Genetic analysis of DNA samples from 180 patients with uterine leiomyoma (UL) and 98 women of the control group without UL showed that the frequency of homozygous AA variant of IL17A -197G/A gene polymorphism was significantly increased in UL (odds ratio, OR = 4.33; p = 0.0096). The frequency of this variant was even more increased when it is combined with homozygote variants GG at positions 238 and 308 of the TNF gene. The combination of the genotypes of these polymorphisms in the AA-GG-GG positions is not only widespread among patients with UL (OR = 12.22; p = 0.0054), but also was not detected in the control group. On the contrary, heterozygous IL17A -197 GA in combination with TNF-863C/A, TNF-308G/A, TNF-238G/A, IL1B-31T/C, IL6-174C/G, and IL8-251T/A are detected significantly less frequently among patients with UL than in the control, with taking into account Bonferroni's correction for the multiplicity of comparisons. The results obtained can be used in the personalized prognosis of predisposition to UL.

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子宫平滑肌瘤中IL17A多态性变异与TNF、IL1B、IL6和IL8促炎因子基因变异的替代组合

对180例子宫平滑肌瘤（UL）患者和98例未患UL的对照组的DNA样本进行遗传分析发现，IL17A -197G/A基因多态性纯合子AA变体在UL中的频率显著增加(优势比，OR = 4.33；P = 0.0096)。当它与TNF基因238和308位的纯合子变异GG结合时，这种变异的频率甚至更高。这些基因型多态性在AA-GG-GG位点的组合不仅广泛存在于UL患者中(OR = 12.22；P = 0.0054)，但在对照组中也未发现。相反，考虑到Bonferroni校正的比较多样性，在UL患者中检测到杂合子IL17A -197 GA与TNF-863C/A、TNF-308G/A、TNF-238G/A、IL1B-31T/C、IL6-174C/G和IL8-251T/A的频率明显低于对照组。所得结果可用于UL易感性的个性化预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.