{"title":"The association of rs7041 polymorphism with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome.","authors":"Hediyeh Hamidi, Asma Kheirollahi, Akram Vatannejad","doi":"10.1186/s13104-025-07312-1","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to examine the association of rs7041 polymorphism with PCOS, as well as infertility and recurrent pregnancy loss (RPL) in PCOS patients.</p><p><strong>Results: </strong>Genotype analysis showed that the GT genotype and the T allele of the rs7041 polymorphism were associated with increased odds of PCOS. (OR: 2.8 95% CI [1.48-5.33], p = 0.002, and OR: 2.27 95% CI [1.2-4.28], p = 0.01, respectively). Furthermore, the GT genotype and T allele of the rs7041 polymorphism were associated with increased odds of infertility in women with PCOS. (OR: 40.55 95% CI [5.34-307.7], p < 0.0001, and OR: 30.667 95% CI [4.05-232.19], p = 0.001, respectively). Conversely, no significant association was observed between genotypes and RPL in women with PCOS. Luteinizing hormone (LH) levels were significantly higher in individuals with the T allele compared to those with the G allele.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"242"},"PeriodicalIF":1.6000,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126907/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Research Notes","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s13104-025-07312-1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: This study aimed to examine the association of rs7041 polymorphism with PCOS, as well as infertility and recurrent pregnancy loss (RPL) in PCOS patients.
Results: Genotype analysis showed that the GT genotype and the T allele of the rs7041 polymorphism were associated with increased odds of PCOS. (OR: 2.8 95% CI [1.48-5.33], p = 0.002, and OR: 2.27 95% CI [1.2-4.28], p = 0.01, respectively). Furthermore, the GT genotype and T allele of the rs7041 polymorphism were associated with increased odds of infertility in women with PCOS. (OR: 40.55 95% CI [5.34-307.7], p < 0.0001, and OR: 30.667 95% CI [4.05-232.19], p = 0.001, respectively). Conversely, no significant association was observed between genotypes and RPL in women with PCOS. Luteinizing hormone (LH) levels were significantly higher in individuals with the T allele compared to those with the G allele.
目的：探讨rs7041基因多态性与PCOS、不孕症及复发性妊娠丢失（RPL）的关系。结果：基因型分析显示，GT基因型和rs7041多态性的T等位基因与PCOS的发病率增加相关。(或:2.8 95%可信区间(1.48 - -5.33),p = 0.002,或:2.27 - 95% CI [1.2 - -4.28], p = 0.01)。此外，GT基因型和rs7041多态性的T等位基因与PCOS女性不孕的几率增加有关。(OR: 40.55 95% CI [5.34-307.7], p
BMC Research NotesBiochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
3.60
自引率
0.00%
发文量
363
审稿时长
15 weeks
期刊介绍：
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