Resveratrol reverses cassava (Manihot esculenta Crantz) juice-induced motor impairment in the Wistar rat.

IF 3.3 2区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE
Eduardo Rivadeneyra-Domínguez, Isaac Zamora-Bello, Erik Raúl Juárez-Zaragoza, Óscar Rosales-Sánchez, Gabriel Guillén-Ruiz, Juan Francisco Rodríguez-Landa
{"title":"Resveratrol reverses cassava (Manihot esculenta Crantz) juice-induced motor impairment in the Wistar rat.","authors":"Eduardo Rivadeneyra-Domínguez, Isaac Zamora-Bello, Erik Raúl Juárez-Zaragoza, Óscar Rosales-Sánchez, Gabriel Guillén-Ruiz, Juan Francisco Rodríguez-Landa","doi":"10.1186/s12906-025-04934-7","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Long-term cassava (Manihot esculenta Crantz) intake has been associated with the development of neurological diseases characterized by motor impairment in humans and experimental animals. Thus, there is a need to identify the therapeutic effects of molecules to ameliorate said alterations, such as resveratrol, which was explored in the present study. Therefore, we evaluate whether the behavioral alterations associated with the chronic intake of cassava juice could be reversed with resveratrol.</p><p><strong>Methods: </strong>Adult male rats were randomly assigned to four independent groups (n = 8): vehicle (purified water), cassava (28.56 mg/kg), resveratrol (10.70 mg/kg), and a combination of treatments (cassava plus resveratrol). Vehicle and cassava juices were administered from days 1 to 28, followed by vehicle or resveratrol from days 29 to 56. The effects of the treatments were evaluated on days 28 and 56 in the open field test, rotarod, and swimming test, compared with the baseline.</p><p><strong>Results: </strong>Cassava juice increased crossing, rearing, and grooming in the open field, produced a short latency to fall from the rotarod, and increased the spin behavior and the total time of immobility in the swimming test. These effects were reversed by resveratrol.</p><p><strong>Conclusions: </strong>Resveratrol could be considered in the development of therapeutic strategies for neurological disorders associated with cassava consumption.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"193"},"PeriodicalIF":3.3000,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125863/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Complementary Medicine and Therapies","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12906-025-04934-7","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Long-term cassava (Manihot esculenta Crantz) intake has been associated with the development of neurological diseases characterized by motor impairment in humans and experimental animals. Thus, there is a need to identify the therapeutic effects of molecules to ameliorate said alterations, such as resveratrol, which was explored in the present study. Therefore, we evaluate whether the behavioral alterations associated with the chronic intake of cassava juice could be reversed with resveratrol.

Methods: Adult male rats were randomly assigned to four independent groups (n = 8): vehicle (purified water), cassava (28.56 mg/kg), resveratrol (10.70 mg/kg), and a combination of treatments (cassava plus resveratrol). Vehicle and cassava juices were administered from days 1 to 28, followed by vehicle or resveratrol from days 29 to 56. The effects of the treatments were evaluated on days 28 and 56 in the open field test, rotarod, and swimming test, compared with the baseline.

Results: Cassava juice increased crossing, rearing, and grooming in the open field, produced a short latency to fall from the rotarod, and increased the spin behavior and the total time of immobility in the swimming test. These effects were reversed by resveratrol.

Conclusions: Resveratrol could be considered in the development of therapeutic strategies for neurological disorders associated with cassava consumption.

Clinical trial number: Not applicable.

白藜芦醇可逆转木薯汁引起的Wistar大鼠运动障碍。
背景:长期摄入木薯(Manihot esculenta Crantz)与人类和实验动物中以运动障碍为特征的神经系统疾病的发展有关。因此,有必要确定分子的治疗效果,以改善这些改变,如白藜芦醇,这是在本研究中探索的。因此,我们评估与长期摄入木薯汁相关的行为改变是否可以用白藜芦醇逆转。方法:将成年雄性大鼠随机分为4个独立组(n = 8):对照物(纯净水)、木薯(28.56 mg/kg)、白藜芦醇(10.70 mg/kg)和木薯+白藜芦醇联合处理。第1 ~ 28天分别给药和木薯汁,第29 ~ 56天分别给药和白藜芦醇。与基线相比,在第28天和第56天进行空地试验、旋转试验和游泳试验,评估处理的效果。结果:木薯汁增加了裸地的杂交、饲养和梳理,产生了较短的从旋转杆上坠落的潜伏期,增加了游泳试验中的旋转行为和总静止时间。这些作用被白藜芦醇逆转了。结论:白藜芦醇可用于开发与木薯消费相关的神经系统疾病的治疗策略。临床试验号:不适用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
BMC Complementary Medicine and Therapies
BMC Complementary Medicine and Therapies INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
6.10
自引率
2.60%
发文量
300
审稿时长
19 weeks
期刊介绍:
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信