The effect of epilepsy on anxiety, depression, as well as prognostic value among adult low-grade gliomas patients

IF 2.7 4区医学 Q3 NEUROSCIENCES

Brain Research Pub Date : 2025-05-29 DOI:10.1016/j.brainres.2025.149737

Kun Zhao, Jiayu Gu, Beichuan Zhao

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引用次数: 0

Abstract

Background

Epilepsy, anxiety and depression are frequently discussed in patients with gliomas, but limited study focused on adult low-grade gliomas (LGG) patients with epilepsy. Hence, this study aimed to compare the prevalence of anxiety and depression in adult LGG patients with epilepsy and without epilepsy, and investigate the prognostic value of epilepsy before surgery in these patients.

Methods

A prospective study of 96 adult LGG patients with epilepsy, and 151 adult LGG patients without epilepsy were enrolled to measure anxiety and depression before surgery, 6 months after surgery, 12 months after surgery. All these patients were followed up to death or 36 months.

Results

We found that the prevalence of preoperative anxiety in adult LGG patients with epilepsy was 62.5% to 63.5%, which was higher than the prevalence of preoperative anxiety in adult LGG patients without epilepsy, which was 45.7% to 47.7%. The prevalence of preoperative depression in adult LGG patients with epilepsy was 61.5% to 62.5%, which was much higher than 47.7% to 48.3% in non-epileptic patients. We found no differences in postoperative anxiety between patients with epilepsy and without epilepsy. Epilepsy before surgery was associated with shorter progression-free survival (PFS) in adult LGG patients.

Conclusion

This study indicated that the prevalence of anxiety and depression were higher in adult LGG patients with epilepsy than without epilepsy. The prognostic value of epilepsy may contribute to early prevention and improvement of prognosis in adult LGG patients with epilepsy.

查看原文本刊更多论文

癫痫对成人低级别胶质瘤患者焦虑、抑郁的影响及其预后价值。

背景：神经胶质瘤患者常被讨论癫痫、焦虑和抑郁，但对成人低级别神经胶质瘤（LGG）合并癫痫患者的研究有限。因此，本研究旨在比较合并癫痫和未合并癫痫的成年LGG患者焦虑和抑郁的患病率，探讨术前癫痫对这些患者的预后价值。方法：前瞻性研究纳入96例合并癫痫的成年LGG患者和151例未患癫痫的成年LGG患者，分别于术前、术后6 个月、术后12 个月测量焦虑和抑郁水平。所有患者均随访至死亡或36 个月。结果：我们发现合并癫痫的成年LGG患者术前焦虑患病率为62.5% ~ 63.5%，高于未合并癫痫的成年LGG患者术前焦虑患病率为45.7% ~ 47.7%。成年LGG伴癫痫患者术前抑郁患病率为61.5% ~ 62.5%，远高于非癫痫患者的47.7% ~ 48.3%。我们发现癫痫患者和非癫痫患者术后焦虑无差异。成人LGG患者术前癫痫与较短的无进展生存期（PFS）相关。结论：本研究表明，成年LGG患者伴癫痫的焦虑和抑郁发生率高于未伴癫痫的患者。癫痫的预后价值可能有助于早期预防和改善成年LGG癫痫患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Research 医学-神经科学

CiteScore

5.90

自引率

3.40%

发文量

268

审稿时长

47 days

期刊介绍： An international multidisciplinary journal devoted to fundamental research in the brain sciences. Brain Research publishes papers reporting interdisciplinary investigations of nervous system structure and function that are of general interest to the international community of neuroscientists. As is evident from the journals name, its scope is broad, ranging from cellular and molecular studies through systems neuroscience, cognition and disease. Invited reviews are also published; suggestions for and inquiries about potential reviews are welcomed. With the appearance of the final issue of the 2011 subscription, Vol. 67/1-2 (24 June 2011), Brain Research Reviews has ceased publication as a distinct journal separate from Brain Research. Review articles accepted for Brain Research are now published in that journal.