Erythema Nodosum in Hidradenitis Suppurativa: A Case Series

Katie K. Lovell, Sujeeth Shanmugam, Steven R. Feldman, Rita Pichardo
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引用次数: 0

Abstract

Hidradenitis suppurativa (HS) is a chronic inflammatory condition linked to dermatologic and multisystem comorbidities, including pyoderma gangrenosum, arthritis, inflammatory bowel disease, and Behcet's disease. While associations with immunological and inflammatory conditions are less frequently reported, erythema nodosum (EN) has an adjusted odds ratio of 8.36 in HS patients. Erythema nodosum, a type IV hypersensitivity reaction, is a panniculitis characterized by acute inflammation triggered by factors such as dimorphic fungal infections, tuberculosis, sarcoidosis, and medications like oral contraceptives and antibiotics. A link between EN and tumor necrosis factor alpha (TNF-ɑ) inhibitors is suggested by case reports. Adalimumab is used in the treatment of moderate-to-severe HS, and EN in these patients could be related to the drug or the disease. This case series describes cases of EN in patients with HS and the relationship with adalimumab exposure.

化脓性汗腺炎并发结节性红斑:一个病例系列
化脓性汗腺炎(HS)是一种慢性炎症性疾病,与皮肤病和多系统合并症有关,包括坏疽性脓皮病、关节炎、炎症性肠病和白塞病。虽然与免疫和炎症相关的报道较少,但结节性红斑(EN)在HS患者中的调整优势比为8.36。结节性红斑是一种IV型超敏反应,是由二型真菌感染、结核、结节病和口服避孕药、抗生素等药物等因素引发的急性炎症。病例报告表明EN与肿瘤坏死因子α (TNF- α)抑制剂之间存在联系。阿达木单抗用于治疗中重度HS,这些患者的EN可能与药物或疾病有关。本病例系列描述了HS患者的EN病例及其与阿达木单抗暴露的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
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