Sustained Enlargement in Vagus and Sural Nerve Cross-Sectional Areas in Fibromyalgia: A Longitudinal Study

IF 2.3 4区 医学 Q3 CLINICAL NEUROLOGY
Benedetta Bianchi, Edoardo Cipolletta, Sonia Farah, Fausto Salaffi, Marco Di Carlo
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Abstract

Background and Purpose

Fibromyalgia (FM) is a complex condition with unclear pathophysiology. While central sensitization is commonly accepted as the predominant cause of pain symptoms, numerous evidences suggest a role for the peripheral nervous system, particularly small fiber neuropathy. Previous studies have documented that patients with FM show an increased cross-sectional area (CSA) of some nerves, including the vagus and sural nerves, detectable via ultrasound (US). The purpose of this study is to assess whether the CSA increase persists over time and to investigate potential correlations between nerve dimensions and clinical variables.

Methods

This study involved 32 female patients with FM and 20 healthy controls, both evaluated at baseline and after 24 months. Participants completed clinimetric questionnaires addressing disease severity, neuropathic pain features, and autonomic dysfunction, while US measurements of the vagus and sural nerves' CSA were taken. Differences in CSA variation were assessed with student's t-test and chi-square, and the Pearson's correlation coefficient tested relationships between nerve dimensions and clinimetric scores.

Results

CSA values were higher in FM patients compared to controls at both baseline and after 24 months, although no significant differences in CSA changes were found over time. Pearson's correlation revealed some associations between nerve dimensions and clinimetric scores, suggesting potential relationships that require further investigation.

Conclusions

FM patients exhibit persistent increases in the vagus and sural nerves CSAs. Further studies are needed to better understand the clinical significance of these findings and the role of US assessment as a tool for detecting nerve alterations in FM.

Abstract Image

纤维肌痛患者迷走神经和腓肠神经横截面积持续增大:一项纵向研究
背景与目的纤维肌痛(FM)是一种病理生理不明确的复杂疾病。虽然中枢致敏通常被认为是疼痛症状的主要原因,但许多证据表明周围神经系统,特别是小纤维神经病变也起作用。先前的研究表明,FM患者表现出一些神经的横截面积(CSA)增加,包括迷走神经和腓肠神经,通过超声(US)检测。本研究的目的是评估CSA是否随时间持续增加,并研究神经尺寸与临床变量之间的潜在相关性。方法本研究纳入32名女性FM患者和20名健康对照者,分别在基线和24个月后进行评估。参与者完成了关于疾病严重程度、神经性疼痛特征和自主神经功能障碍的临床调查问卷,同时进行了迷走神经和腓肠神经CSA的美国测量。采用学生t检验和卡方检验评估CSA变异的差异,Pearson相关系数检验神经尺寸与临床评分之间的关系。结果在基线和24个月后,FM患者的CSA值均高于对照组,尽管随着时间的推移,CSA变化没有显著差异。Pearson的相关性揭示了神经尺寸和临床评分之间的一些关联,这表明潜在的关系需要进一步的研究。结论FM患者迷走神经和腓肠神经csa持续增高。需要进一步的研究来更好地了解这些发现的临床意义以及US评估作为检测FM神经改变的工具的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Neuroimaging
Journal of Neuroimaging 医学-核医学
CiteScore
4.70
自引率
0.00%
发文量
117
审稿时长
6-12 weeks
期刊介绍: Start reading the Journal of Neuroimaging to learn the latest neurological imaging techniques. The peer-reviewed research is written in a practical clinical context, giving you the information you need on: MRI CT Carotid Ultrasound and TCD SPECT PET Endovascular Surgical Neuroradiology Functional MRI Xenon CT and other new and upcoming neuroscientific modalities.The Journal of Neuroimaging addresses the full spectrum of human nervous system disease, including stroke, neoplasia, degenerating and demyelinating disease, epilepsy, tumors, lesions, infectious disease, cerebral vascular arterial diseases, toxic-metabolic disease, psychoses, dementias, heredo-familial disease, and trauma.Offering original research, review articles, case reports, neuroimaging CPCs, and evaluations of instruments and technology relevant to the nervous system, the Journal of Neuroimaging focuses on useful clinical developments and applications, tested techniques and interpretations, patient care, diagnostics, and therapeutics. Start reading today!
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