Supercritical carbon dioxide extraction of Polygonum cuspidatum powders: Experiments and modelling

IF 1.6 4区 工程技术 Q3 ENGINEERING, CHEMICAL
Min Guo, Ningjie Ruan, Bingxu Yao, Shijie Sheng, Xiaoping Li, Yafeng Zhu, Yukun Liu, Zhen Jiao
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引用次数: 0

Abstract

In recent years, the natural anticancer components resveratrol and emodin have attracted significant attention. This study employs supercritical carbon dioxide (ScCO2) extraction, using ethanol as a cosolvent, to extract resveratrol and emodin from Polygonum cuspidatum powders. Experiments were conducted at temperatures ranging from 308 to 328 K, pressures from 15 to 30 MPa, ethanol contents of 60 to 160 mL/L, and extraction times between 1800 and 7200 s. The maximum extraction yields of resveratrol and emodin were 2.516 and 2.765 mg/g, respectively, under optimal conditions (temperature: 323 K, pressure: 25 MPa, ethanol content: 100 mL/L, extraction time: 3600 s), determined through one-way experiments. Additionally, a mathematical model of the ScCO2 extraction process was developed. The mass transfer coefficient (Kf) was used as a fitting parameter and the kinetic model, based on mass conservation, was validated with experimental data. The model demonstrated good accuracy, with a low average absolute relative deviation (AARD) of 4.05%. This model provides theoretical support for industrial scaling and process optimization, achieving maximum extraction efficiency while minimizing CO₂ and ethanol consumption, thereby reducing costs and enhancing environmental benefits. Its establishment framework and methodology offer valuable references for optimizing similar ScCO2 extraction processes.

虎杖粉的超临界二氧化碳萃取:实验与模型
近年来,天然抗癌成分白藜芦醇和大黄素引起了人们的极大关注。本研究采用超临界二氧化碳(ScCO2)萃取法,以乙醇为助溶剂,从虎杖粉末中提取白藜芦醇和大黄素。实验温度308 ~ 328 K,压力15 ~ 30 MPa,乙醇含量60 ~ 160 mL/L,提取时间1800 ~ 7200 s。在最佳提取条件(温度323 K,压力25 MPa,乙醇含量100 mL/L,提取时间3600 s)下,通过单向实验确定白藜芦醇和大黄素的最大提取率分别为2.516和2.765 mg/g。此外,建立了ScCO2萃取过程的数学模型。采用传质系数(Kf)作为拟合参数,利用实验数据对基于质量守恒的动力学模型进行了验证。该模型具有较好的精度,平均绝对相对偏差(AARD)为4.05%。该模型为工业规模化和工艺优化提供理论支持,在实现萃取效率最大化的同时,最大限度地减少二氧化碳和乙醇的消耗,从而降低成本,提高环境效益。其建立框架和方法为类似ScCO2萃取工艺的优化提供了有价值的参考。
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来源期刊
Canadian Journal of Chemical Engineering
Canadian Journal of Chemical Engineering 工程技术-工程:化工
CiteScore
3.60
自引率
14.30%
发文量
448
审稿时长
3.2 months
期刊介绍: The Canadian Journal of Chemical Engineering (CJChE) publishes original research articles, new theoretical interpretation or experimental findings and critical reviews in the science or industrial practice of chemical and biochemical processes. Preference is given to papers having a clearly indicated scope and applicability in any of the following areas: Fluid mechanics, heat and mass transfer, multiphase flows, separations processes, thermodynamics, process systems engineering, reactors and reaction kinetics, catalysis, interfacial phenomena, electrochemical phenomena, bioengineering, minerals processing and natural products and environmental and energy engineering. Papers that merely describe or present a conventional or routine analysis of existing processes will not be considered.
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