Serum Levels of Nitric Oxide, SIRT1, MMP-9 and Telomerase in Children With Cognitive Disengagement Syndrome

IF 1.7 4区医学 Q3 DEVELOPMENTAL BIOLOGY

International Journal of Developmental Neuroscience Pub Date : 2025-06-02 DOI:10.1002/jdn.70024

Sema Öznur Çeltik, Arif Önder, Berhan Akdağ, Sadıka Halide Akbaş, Berke Öztürk, Mehmet Emre Gül, Mehmet Fatih Bütün, Hilal Yazıcı Kopuz, Özge Gizli Çoban, Aslı Sürer Adanır

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Abstract

This study aimed to evaluate serum levels of matrix metalloproteinase-9 (MMP-9), telomerase, sirtuin-1 (SIRT1) and nitric oxide (NO) in children diagnosed with cognitive disengagement syndrome (CDS). The sample included 22 children with ‘pure’ CDS and 42 healthy controls. Our findings indicated that serum levels of telomerase and SIRT1 were significantly elevated in the CDS group compared to the control group, while levels of MMP-9 and NO were significantly reduced. When adjusting for age and gender, the presence of CDS significantly predicted higher serum telomerase levels and lower serum MMP-9 and NO levels. However, it was not a significant predictor of serum levels of SIRT1. Additionally, the serum levels of telomerase and SIRT1 were positively related to the severity of daydreaming symptoms in the CDS group but not to sluggishness. This investigation is the first to explore serum levels of MMP-9, SIRT1, telomerase and NO in children with CDS. The results suggest that these biomarkers may serve as potential tools for diagnosing and monitoring CDS. Additional research is required to elucidate the relationship of these biomarkers to specific CDS symptoms, such as daydreaming and sluggishness.

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认知脱离综合征儿童血清一氧化氮、SIRT1、MMP-9和端粒酶水平的变化

本研究旨在评估被诊断为认知脱离综合征（CDS）的儿童血清基质金属蛋白酶-9 （MMP-9）、端粒酶、sirtuin-1 （SIRT1）和一氧化氮（NO）水平。样本包括22名患有“纯”CDS的儿童和42名健康对照。我们的研究结果表明，与对照组相比，CDS组血清端粒酶和SIRT1水平显著升高，而MMP-9和NO水平显著降低。当调整年龄和性别时，CDS的存在显著预测血清端粒酶水平升高，血清MMP-9和NO水平降低。然而，它不是血清SIRT1水平的显著预测因子。此外，端粒酶和SIRT1的血清水平与CDS组白日梦症状的严重程度呈正相关，而与懒惰无关。这项研究首次探讨了CDS患儿血清中MMP-9、SIRT1、端粒酶和NO的水平。结果表明，这些生物标志物可能作为诊断和监测CDS的潜在工具。需要进一步的研究来阐明这些生物标志物与特定的CDS症状（如白日梦和懒惰）的关系。

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来源期刊

International Journal of Developmental Neuroscience 医学-发育生物学

CiteScore

3.30

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： International Journal of Developmental Neuroscience publishes original research articles and critical review papers on all fundamental and clinical aspects of nervous system development, renewal and regeneration, as well as on the effects of genetic and environmental perturbations of brain development and homeostasis leading to neurodevelopmental disorders and neurological conditions. Studies describing the involvement of stem cells in nervous system maintenance and disease (including brain tumours), stem cell-based approaches for the investigation of neurodegenerative diseases, roles of neuroinflammation in development and disease, and neuroevolution are also encouraged. Investigations using molecular, cellular, physiological, genetic and epigenetic approaches in model systems ranging from simple invertebrates to human iPSC-based 2D and 3D models are encouraged, as are studies using experimental models that provide behavioural or evolutionary insights. The journal also publishes Special Issues dealing with topics at the cutting edge of research edited by Guest Editors appointed by the Editor in Chief. A major aim of the journal is to facilitate the transfer of fundamental studies of nervous system development, maintenance, and disease to clinical applications. The journal thus intends to disseminate valuable information for both biologists and physicians. International Journal of Developmental Neuroscience is owned and supported by The International Society for Developmental Neuroscience (ISDN), an organization of scientists interested in advancing developmental neuroscience research in the broadest sense.