Impact of Gut and Reproductive Tract Microbiota on Estrogen Metabolism in Endometriosis

IF 2.4 3区医学 Q3 IMMUNOLOGY

American Journal of Reproductive Immunology Pub Date : 2025-06-02 DOI:10.1111/aji.70109

ZeFeng Li, ZhaoFang Yin, WeiQi Chen, ZhiHong Wang

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引用次数: 0

Abstract

Background

The incidence of endometriosis is rising, particularly among younger populations, yet current diagnostic and therapeutic approaches remain limited. This highlights the urgent need for novel diagnostic tools and effective treatments. Recent studies have shown that intestinal and reproductive tract bacterial dysbiosis is closely associated with the development of endometriosis and plays a key role in the regulation of estrogen metabolism.

Objectives

This review aims to provide a comprehensive overview of the mechanisms of the microbiota's role in regulating estrogen levels and influencing the development and progression of endometriosis, providing important insights into the diagnosis and management of the disease.

Conclusions

Microbial changes not only promote estrogen imbalance by regulating β-glucuronidase activity, but also respond to estrogen imbalance by affecting the expression of metabolites such as short-chain fatty acids and lipopolysaccharides. In addition, significant fluctuations in estrogen levels also affect the composition of the microbial community. Both factors jointly lead to changes in the immune microenvironment of endometriosis.

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肠道和生殖道微生物群对子宫内膜异位症雌激素代谢的影响

背景子宫内膜异位症的发病率正在上升，尤其是在年轻人群中，但目前的诊断和治疗方法仍然有限。这表明迫切需要新的诊断工具和有效的治疗方法。近期研究表明，肠道和生殖道细菌生态失调与子宫内膜异位症的发生密切相关，并在调节雌激素代谢中起关键作用。本综述旨在全面综述微生物群在调节雌激素水平和影响子宫内膜异位症发生进展中的作用机制，为该病的诊断和治疗提供重要见解。结论微生物变化不仅通过调节β-葡萄糖醛酸酶活性促进雌激素失衡，还通过影响短链脂肪酸、脂多糖等代谢物的表达来应对雌激素失衡。此外，雌激素水平的显著波动也会影响微生物群落的组成。这两种因素共同导致子宫内膜异位症免疫微环境的改变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Reproductive Immunology 医学-免疫学

CiteScore

6.20

自引率

5.60%

发文量

314

审稿时长

2 months

期刊介绍： The American Journal of Reproductive Immunology is an international journal devoted to the presentation of current information in all areas relating to Reproductive Immunology. The journal is directed toward both the basic scientist and the clinician, covering the whole process of reproduction as affected by immunological processes. The journal covers a variety of subspecialty topics, including fertility immunology, pregnancy immunology, immunogenetics, mucosal immunology, immunocontraception, endometriosis, abortion, tumor immunology of the reproductive tract, autoantibodies, infectious disease of the reproductive tract, and technical news.