Study of photothermal properties, antimicrobial activity and biological functions of porous tantalum modified by Cu2+ and Sr2+ doping hydroxyapatite@polydopamine

IF 6.3 2区材料科学 Q2 CHEMISTRY, PHYSICAL

Applied Surface Science Pub Date : 2025-06-01 DOI:10.1016/j.apsusc.2025.163640

Anqi Cai , Hairong Yin , Cuicui Wang , Hao Wan , Linru Wang , Lipeng Qian

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Abstract

Porous tantalum, with its bone tissue-matching biomechanical compatibility and three-dimensional interconnected porous structure, serves as an ideal carrier material for bone defect repair. To address the limited functionality of conventional hydroxyapatite coatings, this study developed a polydopamine-modified copper/strontium co-doped hydroxyapatite composite system through a synergistic doping strategy. Experimental results demonstrated that sustained copper ion release (0.451 ppm over 21 days) endowed the material with persistent antibacterial capability, while strontium ion release (11.847 ppm) significantly enhanced osteoblast alkaline phosphatase (ALP) activity by 2.8-fold. The polydopamine coating achieved a photothermal conversion efficiency of 68.83 %, exhibiting a bacterial inactivation rate exceeding 99.9 % against Escherichia coli under near-infrared irradiation. Cytotoxicity evaluation confirmed that material extracts caused no negative impact on MC3T3-E1 cell viability (>95 %), with ion release concentrations consistently below safety thresholds (Cu < 1 ppm, Sr < 100 ppm). This work lays the foundation for developing novel bone repair materials integrating osteoinductive and intelligent antibacterial functions.

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Cu2+和Sr2+掺杂改性多孔钽的光热性质、抗菌活性和生物功能研究hydroxyapatite@polydopamine

多孔钽具有与骨组织匹配的生物力学相容性和三维互联多孔结构，是骨缺损修复的理想载体材料。为了解决传统羟基磷灰石涂层功能有限的问题，本研究通过协同掺杂策略开发了一种聚多巴胺修饰的铜/锶共掺杂羟基磷灰石复合体系。实验结果表明，铜离子持续释放（0.451 ppm, 21 d）使材料具有持久的抗菌能力，而锶离子释放（11.847 ppm）使材料的成骨细胞碱性磷酸酶（ALP）活性显著提高2.8倍。聚多巴胺包被光热转换效率为68.83 %，近红外辐照下对大肠杆菌的灭活率超过99.9 %。细胞毒性评估证实，材料提取物对MC3T3-E1细胞活力没有负面影响（>95 %），离子释放浓度始终低于安全阈值（Cu <； 1 ppm, Sr <； 100 ppm）。本研究为开发集骨诱导和智能抗菌功能于一体的新型骨修复材料奠定了基础。

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来源期刊

Applied Surface Science 工程技术-材料科学：膜

CiteScore

12.50

自引率

7.50%

发文量

3393

审稿时长

67 days

期刊介绍： Applied Surface Science covers topics contributing to a better understanding of surfaces, interfaces, nanostructures and their applications. The journal is concerned with scientific research on the atomic and molecular level of material properties determined with specific surface analytical techniques and/or computational methods, as well as the processing of such structures.