Bone loss, osteoporosis, and fractures in patients with resected pancreatic head cancer

IF 2.7 2区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Pancreatology Pub Date : 2025-08-01 DOI:10.1016/j.pan.2025.05.014

Tsuyoshi Takeda , Takashi Sasaki , Yosuke Inoue , Takeshi Okamoto , Tatsuki Hirai , Takafumi Mie , Takaaki Furukawa , Yukari Suzuki , Masato Ozaka , Yu Takahashi , Akio Saiura , Naoki Sasahira

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引用次数: 0

Abstract

Background

Major pancreatic resections are considered to have a high risk of developing osteoporosis. This study aimed to examine factors associated with bone mineral density (BMD) loss, osteoporosis, and fractures among pancreatic head cancer patients who underwent resection.

Methods

We retrospectively investigated consecutive pancreatic head cancer patients who underwent resection and had evaluable computed tomography (CT) before surgery and at one-year follow-up. BMD was measured using CT images at the L1 vertebra. Osteoporosis was defined as BMD <135 Hounsfield units. The prevalence and risk factors for BMD loss, osteoporosis, and fractures were examined.

Results

A total of 364 patients were included. Osteoporosis was associated with older age, higher rate of severe complications, and lower rate of receiving adjuvant chemotherapy. BMD consistently decreased over time regardless of age, sex, or cancer stage, leading to accelerating increase in the prevalence of osteoporosis over time (50.8 % at baseline and 73.1 % at one year). BMD loss was greater in young patients, males, patients with late-stage cancer, and patients who developed postoperative recurrence. Incident fractures developed in 47 patients (12.9 %) during follow-up, which were associated with older age, osteoporosis at the time of surgery, and postoperative recurrence.

Conclusions

Pancreatic head cancer patients who underwent resection showed an increased risk of BMD loss, osteoporosis and fractures. Screening for osteoporosis should be considered in pancreatic head cancer patients who underwent resection.

查看原文本刊更多论文

胰头癌切除术患者的骨质流失、骨质疏松和骨折。

背景：胰腺大切除术被认为有发生骨质疏松的高风险。本研究旨在探讨胰头癌切除术患者骨密度（BMD）丢失、骨质疏松和骨折的相关因素。方法：我们回顾性调查了连续的胰头癌患者，这些患者在术前和随访一年时接受了手术切除并进行了可评估的计算机断层扫描（CT）。使用L1椎体的CT图像测量骨密度。骨质疏松定义为BMD。结果：共纳入364例患者。骨质疏松症与年龄较大、严重并发症发生率较高、接受辅助化疗率较低有关。骨密度随时间持续下降，与年龄、性别或癌症分期无关，导致骨质疏松症患病率随时间加速增加（基线时为50.8%，一年后为73.1%）。年轻患者、男性、晚期癌症患者和术后复发患者的骨密度损失更大。随访期间，47例（12.9%）患者发生偶发性骨折，与年龄较大、手术时骨质疏松和术后复发有关。结论：胰头癌患者行切除后出现骨密度损失、骨质疏松和骨折的风险增加。胰头癌切除术患者应考虑骨质疏松筛查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pancreatology 医学-胃肠肝病学

CiteScore

7.20

自引率

5.60%

发文量

194

审稿时长

44 days

期刊介绍： Pancreatology is the official journal of the International Association of Pancreatology (IAP), the European Pancreatic Club (EPC) and several national societies and study groups around the world. Dedicated to the understanding and treatment of exocrine as well as endocrine pancreatic disease, this multidisciplinary periodical publishes original basic, translational and clinical pancreatic research from a range of fields including gastroenterology, oncology, surgery, pharmacology, cellular and molecular biology as well as endocrinology, immunology and epidemiology. Readers can expect to gain new insights into pancreatic physiology and into the pathogenesis, diagnosis, therapeutic approaches and prognosis of pancreatic diseases. The journal features original articles, case reports, consensus guidelines and topical, cutting edge reviews, thus representing a source of valuable, novel information for clinical and basic researchers alike.