The prenatal development of alkaline phosphatase activity in the hypothalamus of the rat.

Basic and applied histochemistry Pub Date : 1988-01-01
E A Lakke, J G van der Veeken, E Marani
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引用次数: 0

Abstract

The localization of alkaline phosphatase (E.C. 3.1.3.1.) positivity during prenatal development of the hypothalamus of the rat is described. At E12 all layers of the prosencephalon display alkaline phosphatase (AP) positivity. The AP positivity increases from dorsal to ventral. Within the hypothalamic area a second, rostro-ventral gradient exists from E14 onwards. At E18 both gradients have decreased. At E20 almost all AP positivity has disappeared from the hypothalamus, with the exception of some reaction product in the dorsal ventricular matrix of the hypothalamus. The significance of this pattern in relation to the differentiation of the hypothalamus and to the formation of hypothalamic connections is discussed. It is suggested that AP activity is related to the formation of connections.

大鼠下丘脑碱性磷酸酶活性的产前发育。
描述了大鼠下丘脑产前发育过程中碱性磷酸酶(e.c.3.1.3.1)阳性的定位。E12时前脑各层碱性磷酸酶(AP)均呈阳性。AP阳性由背侧向腹侧增加。在下丘脑区域内,从E14开始存在另一种斜向腹侧梯度。在E18,两个梯度都减小了。在E20时,除了下丘脑脑室背基质中的一些反应产物外,下丘脑几乎所有AP阳性都消失了。讨论了这种模式在下丘脑分化和下丘脑连接形成方面的意义。这表明AP活性与连接的形成有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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