Fipronil Tissue Residues and Withdrawal Period Feasibility in Laying Hens After Extra-Label Use.

IF 1.5 4区 农林科学 Q3 PHARMACOLOGY & PHARMACY
Lucila Canton, Andrea Berkovic, Laura Ceballos, Candela Canton, Carlos Lanusse, Luis Alvarez, Laura Moreno
{"title":"Fipronil Tissue Residues and Withdrawal Period Feasibility in Laying Hens After Extra-Label Use.","authors":"Lucila Canton, Andrea Berkovic, Laura Ceballos, Candela Canton, Carlos Lanusse, Luis Alvarez, Laura Moreno","doi":"10.1111/jvp.70002","DOIUrl":null,"url":null,"abstract":"<p><p>Fipronil, a broad-spectrum insecticide, is often used off-label in laying hens to control red mites. This study investigated fipronil residue levels in hen tissues after simulating common extra-label administrations: in-feed (1 mg kg<sup>-1</sup> twice) and transdermal (1 mg kg<sup>-1</sup> once). Fipronil residues were quantified by HPLC-MS/MS. Both administrations resulted in quantifiable residues in edible tissues (muscle, liver, kidney, skin, fat) and feathers for up to 60 days. Fipronil-sulfone, the primary metabolite, was the dominant residue in tissues. Fat accumulated the highest concentrations. In-feed administration led to higher overall residues in edible tissues, while transdermal application resulted in higher concentrations in feathers. Calculated withdrawal periods, based on established MRLs, ranged from 36 days (muscle, transdermal) to 131 days (fat, transdermal). These long withdrawal periods render both administration routes impractical for poultry production. The study highlights the risk of fipronil residues in poultry products and suggests feather/fecal sampling for monitoring illicit use.</p>","PeriodicalId":17596,"journal":{"name":"Journal of veterinary pharmacology and therapeutics","volume":" ","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of veterinary pharmacology and therapeutics","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1111/jvp.70002","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0

Abstract

Fipronil, a broad-spectrum insecticide, is often used off-label in laying hens to control red mites. This study investigated fipronil residue levels in hen tissues after simulating common extra-label administrations: in-feed (1 mg kg-1 twice) and transdermal (1 mg kg-1 once). Fipronil residues were quantified by HPLC-MS/MS. Both administrations resulted in quantifiable residues in edible tissues (muscle, liver, kidney, skin, fat) and feathers for up to 60 days. Fipronil-sulfone, the primary metabolite, was the dominant residue in tissues. Fat accumulated the highest concentrations. In-feed administration led to higher overall residues in edible tissues, while transdermal application resulted in higher concentrations in feathers. Calculated withdrawal periods, based on established MRLs, ranged from 36 days (muscle, transdermal) to 131 days (fat, transdermal). These long withdrawal periods render both administration routes impractical for poultry production. The study highlights the risk of fipronil residues in poultry products and suggests feather/fecal sampling for monitoring illicit use.

超标签使用后氟虫腈在蛋鸡体内的组织残留及停药期可行性。
氟虫腈是一种广谱杀虫剂,经常在标签外用于蛋鸡控制红螨。本研究在模拟常见的标签外用药后调查了氟虫腈在母鸡组织中的残留水平:饲料(1 mg kg-1两次)和透皮(1 mg kg-1一次)。采用HPLC-MS/MS法测定氟虫腈残留量。两种药物都导致可食用组织(肌肉、肝脏、肾脏、皮肤、脂肪)和羽毛中可量化残留长达60天。主要代谢物氟虫腈-砜是组织中的主要残留物。脂肪积聚的浓度最高。饲料中施用导致食用组织中总残留较高,而透皮施用导致羽毛中浓度较高。根据确定的MRLs,计算出的停药期从36天(肌肉,透皮)到131天(脂肪,透皮)不等。这些较长的停药期使得这两种给药途径对家禽生产都是不切实际的。该研究强调了氟虫腈残留在家禽产品中的风险,并建议对羽毛/粪便进行取样以监测非法使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
3.10
自引率
15.40%
发文量
69
审稿时长
8-16 weeks
期刊介绍: The Journal of Veterinary Pharmacology and Therapeutics (JVPT) is an international journal devoted to the publication of scientific papers in the basic and clinical aspects of veterinary pharmacology and toxicology, whether the study is in vitro, in vivo, ex vivo or in silico. The Journal is a forum for recent scientific information and developments in the discipline of veterinary pharmacology, including toxicology and therapeutics. Studies that are entirely in vitro will not be considered within the scope of JVPT unless the study has direct relevance to the use of the drug (including toxicants and feed additives) in veterinary species, or that it can be clearly demonstrated that a similar outcome would be expected in vivo. These studies should consider approved or widely used veterinary drugs and/or drugs with broad applicability to veterinary species.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信