Lucila Canton, Andrea Berkovic, Laura Ceballos, Candela Canton, Carlos Lanusse, Luis Alvarez, Laura Moreno
{"title":"Fipronil Tissue Residues and Withdrawal Period Feasibility in Laying Hens After Extra-Label Use.","authors":"Lucila Canton, Andrea Berkovic, Laura Ceballos, Candela Canton, Carlos Lanusse, Luis Alvarez, Laura Moreno","doi":"10.1111/jvp.70002","DOIUrl":null,"url":null,"abstract":"<p><p>Fipronil, a broad-spectrum insecticide, is often used off-label in laying hens to control red mites. This study investigated fipronil residue levels in hen tissues after simulating common extra-label administrations: in-feed (1 mg kg<sup>-1</sup> twice) and transdermal (1 mg kg<sup>-1</sup> once). Fipronil residues were quantified by HPLC-MS/MS. Both administrations resulted in quantifiable residues in edible tissues (muscle, liver, kidney, skin, fat) and feathers for up to 60 days. Fipronil-sulfone, the primary metabolite, was the dominant residue in tissues. Fat accumulated the highest concentrations. In-feed administration led to higher overall residues in edible tissues, while transdermal application resulted in higher concentrations in feathers. Calculated withdrawal periods, based on established MRLs, ranged from 36 days (muscle, transdermal) to 131 days (fat, transdermal). These long withdrawal periods render both administration routes impractical for poultry production. The study highlights the risk of fipronil residues in poultry products and suggests feather/fecal sampling for monitoring illicit use.</p>","PeriodicalId":17596,"journal":{"name":"Journal of veterinary pharmacology and therapeutics","volume":" ","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of veterinary pharmacology and therapeutics","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1111/jvp.70002","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
Fipronil, a broad-spectrum insecticide, is often used off-label in laying hens to control red mites. This study investigated fipronil residue levels in hen tissues after simulating common extra-label administrations: in-feed (1 mg kg-1 twice) and transdermal (1 mg kg-1 once). Fipronil residues were quantified by HPLC-MS/MS. Both administrations resulted in quantifiable residues in edible tissues (muscle, liver, kidney, skin, fat) and feathers for up to 60 days. Fipronil-sulfone, the primary metabolite, was the dominant residue in tissues. Fat accumulated the highest concentrations. In-feed administration led to higher overall residues in edible tissues, while transdermal application resulted in higher concentrations in feathers. Calculated withdrawal periods, based on established MRLs, ranged from 36 days (muscle, transdermal) to 131 days (fat, transdermal). These long withdrawal periods render both administration routes impractical for poultry production. The study highlights the risk of fipronil residues in poultry products and suggests feather/fecal sampling for monitoring illicit use.
期刊介绍:
The Journal of Veterinary Pharmacology and Therapeutics (JVPT) is an international journal devoted to the publication of scientific papers in the basic and clinical aspects of veterinary pharmacology and toxicology, whether the study is in vitro, in vivo, ex vivo or in silico. The Journal is a forum for recent scientific information and developments in the discipline of veterinary pharmacology, including toxicology and therapeutics. Studies that are entirely in vitro will not be considered within the scope of JVPT unless the study has direct relevance to the use of the drug (including toxicants and feed additives) in veterinary species, or that it can be clearly demonstrated that a similar outcome would be expected in vivo. These studies should consider approved or widely used veterinary drugs and/or drugs with broad applicability to veterinary species.