Expression level and clinical significance of IL-29 in serum of patients with coronary heart disease.

IF 1.5 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Ping Ni, Liming Dai, Hai Li, Jun Sun, Yicheng Zhu, Xiaolei Lv
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引用次数: 0

Abstract

Background: Coronary heart disease (CHD) is a chronic inflammatory disease carrying high morbidity and mortality. Interleukin (IL)-29 may be used as a biomarker for autoimmune diseases. This paper investigates the diagnostic value of serum IL-29 in CHD patients.

Methods: A total of 90 CHD patients (39 mild and 51 severe patients) and 90 controls were included. Serum IL-29 levels were detected by ELISA, and the diagnostic value of IL-29 in CHD was analyzed by ROC curve. According to the median value of serum IL-29 level, CHD patients were categorized into IL-29 low-level group and high-level group. The correlation between IL-29 and pathological indexes of CHD patients was analyzed by chi-square test. SYNTAX score was used to classify CHD patients into mild CHD and moderate/severe CHD. Pearson coefficient analyzed the correlation between IL-29 and CHD severity. Multivariate logistic regression analyzed the risk factors for CHD exacerbation.

Results: IL-29 serum levels were elevated in CHD patients. The AUC for CHD diagnosis by serum IL-29 was 0.789 (65.6% sensitivity and 76.7% specificity). IL-29 was correlated with BMI, PHASE score, and CRP. IL-29 serum level was positively correlated with CHD severity. The AUC for differentiating mild and moderate/severe CHD patients by IL-29 level was 0.739 (70.6% sensitivity and 66.7% specificity). IL-29 was an independent risk factor for CHD exacerbation, and each one-unit increase in IL-29 increased the risk of exacerbation in CHD patients by 1.065-fold.

Conclusion: IL-29 is highly expressed in CHD patients and has auxiliary diagnostic value for CHD.

冠心病患者血清IL-29表达水平及临床意义
背景:冠心病(冠心病)是一种发病率和死亡率高的慢性炎症性疾病。白细胞介素(IL)-29可作为自身免疫性疾病的生物标志物。探讨血清IL-29对冠心病患者的诊断价值。方法:90例冠心病患者(轻度39例,重度51例)和90例对照组。采用ELISA检测血清IL-29水平,采用ROC曲线分析IL-29对冠心病的诊断价值。根据血清IL-29水平中位数将冠心病患者分为IL-29低水平组和高水平组。采用卡方检验分析IL-29与冠心病患者病理指标的相关性。采用SYNTAX评分法将冠心病患者分为轻度冠心病和中/重度冠心病。Pearson系数分析IL-29与冠心病严重程度的相关性。多因素logistic回归分析冠心病加重的危险因素。结果:冠心病患者血清IL-29水平升高。血清IL-29诊断冠心病的AUC为0.789(敏感性65.6%,特异性76.7%)。IL-29与BMI、PHASE评分、CRP相关。血清IL-29水平与冠心病严重程度呈正相关。IL-29水平鉴别轻、中/重度冠心病患者的AUC为0.739(敏感性70.6%,特异性66.7%)。IL-29是冠心病加重的独立危险因素,IL-29每升高1个单位,冠心病患者加重的风险增加1.065倍。结论:IL-29在冠心病患者中高表达,对冠心病有辅助诊断价值。
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来源期刊
Journal of Cardiothoracic Surgery
Journal of Cardiothoracic Surgery 医学-心血管系统
CiteScore
2.50
自引率
6.20%
发文量
286
审稿时长
4-8 weeks
期刊介绍: Journal of Cardiothoracic Surgery is an open access journal that encompasses all aspects of research in the field of Cardiology, and Cardiothoracic and Vascular Surgery. The journal publishes original scientific research documenting clinical and experimental advances in cardiac, vascular and thoracic surgery, and related fields. Topics of interest include surgical techniques, survival rates, surgical complications and their outcomes; along with basic sciences, pediatric conditions, transplantations and clinical trials. Journal of Cardiothoracic Surgery is of interest to cardiothoracic and vascular surgeons, cardiothoracic anaesthesiologists, cardiologists, chest physicians, and allied health professionals.
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