Macrophage migration inhibitory factor (rs755622) gene polymorphism in vitiligo.

IF 1.7 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Irish Journal of Medical Science Pub Date : 2025-05-30 DOI:10.1007/s11845-025-03966-9

Doaa Falih Hadi, Abdel-Aziz Ibrahim El-Taweel, Amany Ibrahim Mustafa, Ola Samir El-Shimi, Mahmoud A Rageh

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引用次数: 0

Abstract

Background: Vitiligo is a cutaneous disease caused by the destruction of functioning melanocytes. Cellular immunity is known to have a role in the pathogenesis of vitiligo. Macrophage migration inhibitory factor (MIF) is a potent activator of macrophages and is considered to play an important role in cell-mediated immunity.

Aims: We tried to investigate the association between MIF (rs755622) gene polymorphism and vitiligo susceptibility and its relationship to severity and clinical types of the disease.

Methods: Fifty patients with vitiligo and 50 healthy controls were included. Determination of MIF gene (rs755622) single nucleotide polymorphism was conducted using polymerase chain reaction (PCR).

Results: There were 18 males and 32 females who had vitiligo, together with 50 control participants of matched age and gender. Taking GG genotype and G allele as references, MIF GC, CC, (GC + CC) genotypes, and C allele demonstrated a substantially higher occurrence in all patients when compared to controls, with a higher risk of developing vitiligo within healthy control subjects.

Conclusions: To the best of our knowledge, this is the third study worldwide and the first from Egypt to investigate the association between MIF gene polymorphism (rs755622) with vitiligo susceptibility and severity, and it showed that MIF gene polymorphism (rs755622) may be considered a risk factor for vitiligo susceptibility. Moreover, it may be associated with higher disease extent.

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巨噬细胞迁移抑制因子（rs755622）基因在白癜风中的多态性。

背景：白癜风是一种由黑色素细胞功能破坏引起的皮肤病。细胞免疫在白癜风的发病机制中起着重要作用。巨噬细胞迁移抑制因子（Macrophage migration inhibitory factor， MIF）是巨噬细胞的一种强效激活因子，被认为在细胞免疫中起重要作用。目的：探讨MIF （rs755622）基因多态性与白癜风易感性的关系及其与病情严重程度和临床分型的关系。方法：选取50例白癜风患者和50例健康对照者。采用聚合酶链反应（PCR）检测MIF基因（rs755622）单核苷酸多态性。结果：白癜风患者男性18人，女性32人，年龄性别相匹配的对照组50人。以GG基因型和G等位基因为参照，MIF GC、CC、（GC + CC）基因型和C等位基因在所有患者中的发生率均明显高于对照组，健康对照者发生白癜风的风险更高。结论：据我们所知，这是世界上第三个，也是埃及第一个研究MIF基因多态性（rs755622）与白癜风易感性和严重程度之间关系的研究，它表明MIF基因多态性（rs755622）可能被认为是白癜风易感性的危险因素。此外，它可能与较高的疾病程度有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Irish Journal of Medical Science 医学-医学：内科

CiteScore

3.70

自引率

4.80%

发文量

357

审稿时长

4-8 weeks

期刊介绍： The Irish Journal of Medical Science is the official organ of the Royal Academy of Medicine in Ireland. Established in 1832, this quarterly journal is a contribution to medical science and an ideal forum for the younger medical/scientific professional to enter world literature and an ideal launching platform now, as in the past, for many a young research worker. The primary role of both the Academy and IJMS is that of providing a forum for the exchange of scientific information and to promote academic discussion, so essential to scientific progress.