Natural therapy proposed for the management of diabetic peripheral neuropathy (DPN).

IF 4.6 2区医学 Q2 IMMUNOLOGY

Inflammopharmacology Pub Date : 2025-05-30 DOI:10.1007/s10787-025-01790-2

Rana M Merghany, Rofida A Saleh, Ahmed A Hamed, Ahmed M El-Dessouki, Riham A El-Shiekh, Eman S Zaki, Amal M Mahfoz

引用次数: 0

Abstract

Approximately 50% of patients with diabetes mellitus (DM) are known to have significant side effects, including retinopathy, cardiomyopathy, peripheral neuropathy, and nephropathy. Most of these complications are caused by inadequate glycemic control or incorrect pathology management. In any event, diabetic peripheral neuropathy (DPN) appears to be the most common and painful consequence that many DM patients experience. As a result, this review aimed to gather the wide range of treatments used to manage DPN, beginning with the most traditional therapy and progressing to alternative approaches. Medicinal plants and their bioactive compounds have been widely used as natural medicines for various diseases, with little known adverse effects. This review emphasizes the role of medicinal plants and their naturally occurring bioactive components in combating this condition.

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自然疗法建议管理糖尿病周围神经病变（DPN）。

大约50%的糖尿病（DM）患者已知有显著的副作用，包括视网膜病变、心肌病、周围神经病变和肾病。这些并发症大多是由于血糖控制不到位或病理处理不正确引起的。在任何情况下，糖尿病周围神经病变（DPN）似乎是许多糖尿病患者经历的最常见和最痛苦的后果。因此，本综述旨在收集用于管理DPN的广泛治疗方法，从最传统的治疗开始，逐步发展到替代方法。药用植物及其生物活性化合物已被广泛用作治疗各种疾病的天然药物，其不良反应鲜为人知。本文综述了药用植物及其天然生物活性成分在防治这一疾病中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Inflammopharmacology IMMUNOLOGYTOXICOLOGY-TOXICOLOGY

CiteScore

8.00

自引率

3.40%

发文量

200

期刊介绍： Inflammopharmacology is the official publication of the Gastrointestinal Section of the International Union of Basic and Clinical Pharmacology (IUPHAR) and the Hungarian Experimental and Clinical Pharmacology Society (HECPS). Inflammopharmacology publishes papers on all aspects of inflammation and its pharmacological control emphasizing comparisons of (a) different inflammatory states, and (b) the actions, therapeutic efficacy and safety of drugs employed in the treatment of inflammatory conditions. The comparative aspects of the types of inflammatory conditions include gastrointestinal disease (e.g. ulcerative colitis, Crohn''s disease), parasitic diseases, toxicological manifestations of the effects of drugs and environmental agents, arthritic conditions, and inflammatory effects of injury or aging on skeletal muscle. The journal has seven main interest areas: -Drug-Disease Interactions - Conditional Pharmacology - i.e. where the condition (disease or stress state) influences the therapeutic response and side (adverse) effects from anti-inflammatory drugs. Mechanisms of drug-disease and drug disease interactions and the role of different stress states -Rheumatology - particular emphasis on methods of measurement of clinical response effects of new agents, adverse effects from anti-rheumatic drugs -Gastroenterology - with particular emphasis on animal and human models, mechanisms of mucosal inflammation and ulceration and effects of novel and established anti-ulcer, anti-inflammatory agents, or antiparasitic agents -Neuro-Inflammation and Pain - model systems, pharmacology of new analgesic agents and mechanisms of neuro-inflammation and pain -Novel drugs, natural products and nutraceuticals - and their effects on inflammatory processes, especially where there are indications of novel modes action compared with conventional drugs e.g. NSAIDs -Muscle-immune interactions during inflammation [...]