A M Kuptsova, A L Zefirov, N I Ziyatdinova, L T Mosolov, T L Zefirov
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引用次数: 0
Abstract
The blockade of hyperpolarization-activated currents (If) (10-9 and 10-5 M) had a multidirectional effect on the left ventricular developed pressure and the maximum contraction rate of the isolated heart in healthy, sham-operated rats, and rats with experimental acute myocardial infarction (AMI). The duration of isolated heart contraction in the presence of the If blocker at both concentrations decreased in the group of healthy animals and did not change in sham-operated rats and rats with AMI. If blockade increased the duration of isolated heart relaxation in all groups. The duration of the contraction cycle under conditions of If blockade (10-9 M) increased in sham-operated rats and rats with AMI and decreased in healthy rats. The maximum concentration of the blocker increased the duration of contraction cycle in all experimental groups.
期刊介绍：
Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005.
World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells.
The Russian Volume Year is published in English from April.
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