Assessment of the Protective Effect of Combined Use of Some Substances in Acute Exposure to Ionizing Radiation in Mice by the Survival Criterion.

IF 0.6 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
L A Romodin, O V Nikitenko, T M Bychkova, E D Rodionova
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引用次数: 0

Abstract

The radioprotective effect of the combined use of radioprotective drugs was studied in a 30-day survival test on male ICR(CD-1) mice exposed to X-ray radiation at a dose of 6.5 Gy. A combination of phenylephrine prior to irradiation, glutathione immediately after irradiation, tocopherol on the next day, and granulocyte CSF for 2 weeks after irradiation ensured complete survival of the irradiated mice. Combined use of chlorophyllin and trolox ensured survival of a half of the irradiated mice. Other schemes were little effective. In some cases, the combined use of certain substances aggravated the condition of irradiated mice. Addition of riboxin to the combination of chlorophyllin and trolox increased mouse mortality compared to the irradiated control group. Copper chlorophyllin and granulocyte CSF were found to be incompatible.

用生存标准评价急性电离辐射照射小鼠几种物质联合使用的保护作用。
在6.5 Gy剂量x射线照射下的雄性ICR(CD-1)小鼠30天生存试验中,研究了放射防护药物联合使用的放射防护作用。照射前联合使用苯肾上腺素,照射后立即联合使用谷胱甘肽,第二天联合使用生育酚,照射后2周联合使用粒细胞CSF确保照射小鼠完全存活。叶绿素和trolox的联合使用确保了一半辐照小鼠的存活。其他方案效果甚微。在某些情况下,某些物质的联合使用加重了受辐射小鼠的状况。与辐射对照组相比,在叶绿素和trolox组合中加入核糖素增加了小鼠死亡率。叶绿素铜与粒细胞CSF不相容。
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来源期刊
Bulletin of Experimental Biology and Medicine
Bulletin of Experimental Biology and Medicine 医学-医学:研究与实验
CiteScore
1.50
自引率
14.30%
发文量
265
审稿时长
2 months
期刊介绍: Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.
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