Zopiclone as a Potent Positive Control for Assessing the Residual Effects of Hypnotic Drugs on Next Day Driving Performance: A Systematic Review

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Human Psychopharmacology: Clinical and Experimental Pub Date : 2025-05-31 DOI:10.1002/hup.70007

Sonali Karhana, Samra Hussain, Mohammad Mateen Zehgeer, Mohd. Ashif Khan

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引用次数: 0

Abstract

Aim

This systematic review aimed to evaluate the efficacy of zopiclone as a potent positive control for the assessment of residual effects of hypnotic drugs on the next day driving performance in clinical trials.

Methodology

Online databases and websites were used to conduct a literature search to identify relevant clinical trials encompassing the use of zopiclone as a positive control and the trials examining the residual effects of zopiclone on the next day driving performance. A total of 22 articles were identified and as per the inclusion criteria, 16 were selected for final data retrieval.

Results

The average difference in Standard Deviation of Lateral Position (SDLP) between zopiclone and a placebo ranged from 1.6 to 4.74 cm. On average, this difference was about 2.51 cm, indicating significant impairment in driving ability the day after taking zopiclone. Therefore, current studies demonstrate zopiclone administration impairs driving performance, as indicated by increased standard deviation of lateral position (SDLP) values. Additionally, the reported adverse events included somnolence, dyspepsia, fatigue, headache, dizziness, gastrointestinal disorders, and upper respiratory tract problems.

Conclusion

Zopiclone can serve as a reliable positive control in future clinical trials assessing the residual effects of hypnotic drugs on next-day driving performance.

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佐匹克隆作为评估催眠药物对第二天驾驶性能残留影响的有效阳性对照：一项系统综述

目的本系统综述旨在评价佐匹克隆在临床试验中作为评估催眠药物残留对次日驾驶性能影响的有效阳性对照的有效性。方法：使用在线数据库和网站进行文献检索，以确定相关的临床试验，包括使用佐匹克隆作为阳性对照，以及检查佐匹克隆对第二天驾驶性能残留影响的试验。共确定了22篇文章，根据纳入标准，选择了16篇文章进行最后的数据检索。结果左匹克隆与安慰剂的侧卧位标准差（SDLP）平均差值为1.6 ~ 4.74 cm。平均差异约为2.51 cm，表明服用佐匹克隆后第二天驾驶能力明显受损。因此，目前的研究表明，佐匹克隆给药会损害驾驶性能，正如横向位置（SDLP）值的标准偏差增加所表明的那样。此外，报告的不良事件包括嗜睡、消化不良、疲劳、头痛、头晕、胃肠道疾病和上呼吸道问题。结论唑匹克隆可作为一种可靠的阳性对照，用于评估催眠药物残留对第二天驾驶性能影响的临床试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human Psychopharmacology: Clinical and Experimental 医学-精神病学

CiteScore

4.10

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Human Psychopharmacology: Clinical and Experimental provides a forum for the evaluation of clinical and experimental research on both new and established psychotropic medicines. Experimental studies of other centrally active drugs, including herbal products, in clinical, social and psychological contexts, as well as clinical/scientific papers on drugs of abuse and drug dependency will also be considered. While the primary purpose of the Journal is to publish the results of clinical research, the results of animal studies relevant to human psychopharmacology are welcome. The following topics are of special interest to the editors and readers of the Journal: -All aspects of clinical psychopharmacology- Efficacy and safety studies of novel and standard psychotropic drugs- Studies of the adverse effects of psychotropic drugs- Effects of psychotropic drugs on normal physiological processes- Geriatric and paediatric psychopharmacology- Ethical and psychosocial aspects of drug use and misuse- Psychopharmacological aspects of sleep and chronobiology- Neuroimaging and psychoactive drugs- Phytopharmacology and psychoactive substances- Drug treatment of neurological disorders- Mechanisms of action of psychotropic drugs- Ethnopsychopharmacology- Pharmacogenetic aspects of mental illness and drug response- Psychometrics: psychopharmacological methods and experimental design