{"title":"AMPAR encephalitis in a child with short-term amnesia after COVID-19 vaccination – A case report","authors":"Melina Alves da Frota , Denise Mendonça Borges , Caroline Corrêa Maranhão , Lidiane Indiani , Marcelo Melo Aragão , Ricardo Silva Pinho","doi":"10.1016/j.hmedic.2025.100264","DOIUrl":null,"url":null,"abstract":"<div><div>We report a 12-year-old boy that developed α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPAR) encephalitis, a rare condition in children, 15 days after receiving the Pfizer-BioNTech COVID-19 vaccine. Initially presenting with short-term amnesia, he showed normal results on EEG and brain MRI. Antibodies against AMPAR were found in his cerebrospinal fluid (CSF). Cancer screenings were normal. The patient was treated with intravenous human immunoglobulin (IVIG) for five days, but relapsed 45 days later. Upon relapse, he received IVIG, dexamethasone, and rituximab, leading to full recovery. While a temporal connection suggests a potential link between vaccination and encephalitis, this has not been previously documented and could be coincidental. Further studies are needed to confirm any causation. Early suspicion and treatment of this condition are crucial for a better prognosis.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100264"},"PeriodicalIF":0.0000,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2949918625001093","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
We report a 12-year-old boy that developed α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPAR) encephalitis, a rare condition in children, 15 days after receiving the Pfizer-BioNTech COVID-19 vaccine. Initially presenting with short-term amnesia, he showed normal results on EEG and brain MRI. Antibodies against AMPAR were found in his cerebrospinal fluid (CSF). Cancer screenings were normal. The patient was treated with intravenous human immunoglobulin (IVIG) for five days, but relapsed 45 days later. Upon relapse, he received IVIG, dexamethasone, and rituximab, leading to full recovery. While a temporal connection suggests a potential link between vaccination and encephalitis, this has not been previously documented and could be coincidental. Further studies are needed to confirm any causation. Early suspicion and treatment of this condition are crucial for a better prognosis.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
