Transporters in vitamin uptake and cellular metabolism: impacts on health and disease.

Life metabolism Pub Date : 2025-03-10 eCollection Date: 2025-06-01 DOI:10.1093/lifemeta/loaf008
Yaxuan Yuan, Ligong Chen
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引用次数: 0

Abstract

Vitamins are vital nutrients essential for metabolism, functioning as coenzymes, antioxidants, and regulators of gene expression. Their absorption and metabolism rely on specialized transport proteins that ensure bioavailability and cellular utilization. Water-soluble vitamins, including B-complex and vitamin C, are transported by solute carrier (SLC) family proteins and ATP-binding cassette (ABC) transporters for efficient uptake and cellular distribution. Fat-soluble vitamins (A, D, E, and K) rely on lipid-mediated pathways through proteins like scavenger receptor class B type I (SR-BI), CD36, and Niemann-Pick C1-like 1 (NPC1L1), integrating their absorption with lipid metabolism. Defective vitamin transporters are associated with diverse metabolic disorders, including neurological, hematological, and mitochondrial diseases. Advances in structural and functional studies of vitamin transporters highlight their tissue-specific roles and regulatory mechanisms, shedding light on their impact on health and disease. This review emphasizes the significance of vitamin transporters and their potential as therapeutic targets for deficiencies and related chronic conditions.

维生素摄取和细胞代谢中的转运体:对健康和疾病的影响。
维生素是新陈代谢必不可少的重要营养素,具有辅酶、抗氧化剂和基因表达调节剂的功能。它们的吸收和代谢依赖于特殊的转运蛋白,以确保生物利用度和细胞利用率。水溶性维生素,包括b复合物和维生素C,通过溶质载体(SLC)家族蛋白和atp结合盒(ABC)转运蛋白进行有效的摄取和细胞分布。脂溶性维生素(A、D、E和K)依赖于通过清道夫受体B类I型(SR-BI)、CD36和尼曼-匹克c1样1 (NPC1L1)等蛋白介导的脂质途径,将其吸收与脂质代谢结合起来。维生素转运蛋白缺陷与多种代谢紊乱有关,包括神经、血液和线粒体疾病。维生素转运体的结构和功能研究的进展突出了其组织特异性作用和调节机制,揭示了它们对健康和疾病的影响。这篇综述强调了维生素转运体的重要性及其作为缺乏和相关慢性疾病的治疗靶点的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
1.10
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