Influence of primary tumor surgical margins on overall survival and local recurrence in patients with squamous cell carcinoma: meta-analysis.

Stomatologija Pub Date : 2024-01-01
Abdulla Varoneckas, Mariam Varoneckaitė, Kotryna Rumšaitė, Marijus Leketas, Algirdas Lukošiūnas, Ričardas Kubilius
{"title":"Influence of primary tumor surgical margins on overall survival and local recurrence in patients with squamous cell carcinoma: meta-analysis.","authors":"Abdulla Varoneckas, Mariam Varoneckaitė, Kotryna Rumšaitė, Marijus Leketas, Algirdas Lukošiūnas, Ričardas Kubilius","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>The aim of this meta-analysis was to determine the influence of surgical margins on the prognostic parameters of patients with oral squamous cell carcinoma.</p><p><strong>Materials and methods: </strong>The literature review was carried out according to PRISMA principles and the database search was performed using following keywords: \"Carcinoma, Squamous Cell (Mesh)\", \"Squamous Cell Carcinoma of Head and Neck (Mesh)\", \"Margins of Excision (Mesh)\". The review included studies with humans, published in English, no longer than 10 years ago, in which patients underwent resection of the primary tumour and the resections were examined histologically and the margins between healthy tissues and tumour were speicified.</p><p><strong>Results: </strong>5 of the included studies examined the impact of surgical margins on overall survival and 10 on local recurrence. In all 5 studies, surgical margins were considered an effective prognostic indicator for the overall survival. Examining the impact of surgical margins on the local recurrence, 7 studies indicated that it is an effective prognostic parameter. Quantitative analysis of the data revealed that a 3 mm surgical margin was safe.</p><p><strong>Conclusions: </strong>Primary tumor surgical margins are an effective prognostic parameter for the overall survival and the local recurrence in patients with oral squamous cell carcinoma. 3 mm surgical margins can be concidered as a safe distance and minimum acceptable separation point between close and involved margins.</p>","PeriodicalId":94215,"journal":{"name":"Stomatologija","volume":"26 1","pages":"3-11"},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Stomatologija","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Aim: The aim of this meta-analysis was to determine the influence of surgical margins on the prognostic parameters of patients with oral squamous cell carcinoma.

Materials and methods: The literature review was carried out according to PRISMA principles and the database search was performed using following keywords: "Carcinoma, Squamous Cell (Mesh)", "Squamous Cell Carcinoma of Head and Neck (Mesh)", "Margins of Excision (Mesh)". The review included studies with humans, published in English, no longer than 10 years ago, in which patients underwent resection of the primary tumour and the resections were examined histologically and the margins between healthy tissues and tumour were speicified.

Results: 5 of the included studies examined the impact of surgical margins on overall survival and 10 on local recurrence. In all 5 studies, surgical margins were considered an effective prognostic indicator for the overall survival. Examining the impact of surgical margins on the local recurrence, 7 studies indicated that it is an effective prognostic parameter. Quantitative analysis of the data revealed that a 3 mm surgical margin was safe.

Conclusions: Primary tumor surgical margins are an effective prognostic parameter for the overall survival and the local recurrence in patients with oral squamous cell carcinoma. 3 mm surgical margins can be concidered as a safe distance and minimum acceptable separation point between close and involved margins.

原发肿瘤手术切缘对鳞状细胞癌患者总生存期和局部复发的影响:荟萃分析
目的:本荟萃分析的目的是确定手术切缘对口腔鳞状细胞癌患者预后参数的影响。材料和方法:按照PRISMA原则进行文献查阅,检索关键词:“Carcinoma, Squamous Cell (Mesh)”,“Squamous Cell Carcinoma of Head and Neck (Mesh)”,“margin of Excision (Mesh)”。这篇综述包括了不超过10年前以英文发表的人类研究,在这些研究中,患者接受了原发肿瘤的切除,并对切除进行了组织学检查,明确了健康组织和肿瘤之间的边缘。结果:纳入的研究中有5项研究考察了手术切缘对总体生存的影响,10项研究考察了局部复发的影响。在所有5项研究中,手术切缘被认为是总体生存的有效预后指标。在研究手术切缘对局部复发的影响时,有7项研究表明它是一个有效的预后参数。定量分析数据显示,3mm的手术切缘是安全的。结论:原发肿瘤手术切缘是口腔鳞状细胞癌患者总体生存和局部复发的有效预后指标。3mm的手术切缘可以被认为是近缘和受累切缘之间的安全距离和最小可接受的分离点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信