Biological functions and molecular mechanisms of circHIPK3 in digestive system tumors.

IF 3.4 3区生物学 Q3 CELL BIOLOGY

Human Cell Pub Date : 2025-05-29 DOI:10.1007/s13577-025-01239-2

Jian Li, Xin Su, Xiao Xu, Youbao Ye, Cailiu Wang, Ang Liu, Changchun Zhao, Wenxiu Liu, Liwen Yang, Tao Wang, Xiangyong Hao

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引用次数: 0

Abstract

Digestive system tumors are the most common tumors worldwide with high mortality rates. Circular homeodomain-interacting protein kinase 3 (circHIPK3) is a highly abundant and stable circular RNA and have garnered significant attention in the field of cancer research. This review systematically explores potential of circHIPK3 as a clinical biomarker, clinical significance in pharmacotherapy, and molecular mechanisms that regulate biological functions such as cell proliferation, survival, migration, invasion, epithelial-mesenchymal transition, metabolism and angiogenesis in digestive system tumors. Moreover, this review further explored the influence of circHIPK3 on key signaling pathways and the potential clinical value as a diagnostic biomarker and therapeutic target. By delving into the biological functions and molecular mechanisms of circHIPK3, this review aims to provide novel research directions and theoretical guidance for the identification of new therapeutic targets and the development of individualized treatment protocols for digestive system tumors.

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circHIPK3在消化系统肿瘤中的生物学功能和分子机制。

消化系统肿瘤是世界上最常见的肿瘤，死亡率高。环状同源结构域相互作用蛋白激酶3 （circHIPK3）是一种丰富而稳定的环状RNA，在癌症研究领域受到了广泛关注。本文系统探讨了circHIPK3作为临床生物标志物的潜力，在药物治疗中的临床意义，以及调节消化系统肿瘤中细胞增殖、存活、迁移、侵袭、上皮-间质转化、代谢和血管生成等生物学功能的分子机制。此外，本综述进一步探讨了circHIPK3对关键信号通路的影响以及作为诊断生物标志物和治疗靶点的潜在临床价值。本文旨在通过深入研究circHIPK3的生物学功能和分子机制，为消化系统肿瘤新的治疗靶点的发现和个体化治疗方案的制定提供新的研究方向和理论指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human Cell CELL BIOLOGY-

CiteScore

5.90

自引率

2.30%

发文量

176

审稿时长

4.5 months

期刊介绍： Human Cell is the official English-language journal of the Japan Human Cell Society. The journal serves as a forum for international research on all aspects of the human cell, encompassing not only cell biology but also pathology, cytology, and oncology, including clinical oncology. Embryonic stem cells derived from animals, regenerative medicine using animal cells, and experimental animal models with implications for human diseases are covered as well. Submissions in any of the following categories will be considered: Research Articles, Cell Lines, Rapid Communications, Reviews, and Letters to the Editor. A brief clinical case report focusing on cellular responses to pathological insults in human studies may also be submitted as a Letter to the Editor in a concise and short format. Not only basic scientists but also gynecologists, oncologists, and other clinical scientists are welcome to submit work expressing new ideas or research using human cells.