Hemolytic uremic syndrome in severe acute pancreatitis.

IF 0.5 Q3 MEDICINE, GENERAL & INTERNAL

Oxford Medical Case Reports Pub Date : 2025-05-28 eCollection Date: 2025-05-01 DOI:10.1093/omcr/omaf048

Jayaraj Hasvi, Inder Preet Singh Bhatia, Saurabh Dawra, Amulyajit Singh, Siddharth Tripathi

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引用次数: 0

Abstract

Introduction: Hemolytic Uremic Syndrome is characterized by Coombs negative microangiopathic hemolytic anemia, severe thrombocytopenia, and acute kidney injury.

Case report: Here, we report a 36-year-old male, a case of alcohol related acute pancreatitis. On day 5, he developed fever and tachycardia. Evaluation revealed thrombocytopenia, hemolytic anemia, and acute kidney injury with low C3, normal C4 & ADAMTS13 activity and positive anti-complement factor H antibody. He was diagnosed as a case of Hemolytic Uremic Syndrome and managed with plasmapheresis, hemodialysis, and Intravenous immunoglobulin. He was administered Rituximab on day 15, considering the refractory nature of the disease. Despite the aggressive management, he succumbed to his illness.

Conclusion: This case highlights atypical Hemolytic Uremic Syndrome as a rare complication of Acute Pancreatitis. Our patient, despite being diagnosed well in time and managed aggressively, had an unfavourable outcome. This condition should be diagnosed well in time, as it is associated with high mortality.

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重症急性胰腺炎的溶血性尿毒症综合征。

溶血性尿毒症综合征以Coombs阴性微血管病性溶血性贫血、严重血小板减少、急性肾损伤为特征。病例报告：在这里，我们报告一个36岁的男性，酒精相关的急性胰腺炎病例。第5天，患者出现发热和心动过速。结果显示血小板减少，溶血性贫血，急性肾损伤，C3低，C4和ADAMTS13活性正常，抗补体因子H抗体阳性。他被诊断为溶血性尿毒症综合征，并接受血浆置换、血液透析和静脉注射免疫球蛋白治疗。考虑到疾病的难治性，患者于第15天给予利妥昔单抗。尽管进行了积极的治疗，他还是病死了。结论：本病例强调非典型溶血性尿毒症综合征是一种罕见的急性胰腺炎并发症。尽管我们的病人得到了及时的诊断和积极的治疗，但结果并不理想。这种情况应及时诊断，因为它与高死亡率有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oxford Medical Case Reports MEDICINE, GENERAL & INTERNAL-

CiteScore

0.90

自引率

0.00%

发文量

125

审稿时长

19 weeks

期刊介绍： Oxford Medical Case Reports (OMCR) is an open access, peer-reviewed online journal publishing original and educationally valuable case reports that expand the field of medicine. The journal covers all medical specialities including cardiology, rheumatology, nephrology, oncology, neurology, and reproduction, comprising a comprehensive resource for physicians in all fields and at all stages of training. Oxford Medical Case Reports deposits all articles in PubMed Central (PMC). Physicians and researchers can find your work through PubMed , helping you reach the widest possible audience. The journal is also indexed in the Web of Science Core Collection . Oxford Medical Case Reports publishes case reports under the following categories: Allergy Audiovestibular medicine Cardiology and cardiovascular systems Critical care medicine Dermatology Emergency medicine Endocrinology and metabolism Gastroenterology and hepatology Geriatrics and gerontology Haematology Immunology Infectious diseases and tropical medicine Medical disorders in pregnancy Medical ophthalmology Nephrology Neurology Oncology Paediatrics Pain Palliative medicine Pharmacology and pharmacy Psychiatry Radiology, nuclear medicine, and medical imaging Respiratory disorders Rheumatology Sexual and reproductive health Sports Medicine Substance abuse.