Effects of brushing with caffeinated toothpaste on neurocognitive function of the central nervous system: a randomized placebo-controlled clinical trial.

IF 3 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Frontiers in oral health Pub Date : 2025-05-15 eCollection Date: 2025-01-01 DOI:10.3389/froh.2025.1470531

Kiarash Zare, Mahva Talaei, Amir Hesam Pahlevani, Fahimeh Rezazadeh, Kiana Zare, Masumeh Akbaryari, Mohammad Mehdi Naghizadeh, Mojtaba Heydari, Mohsen Goharinia

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Abstract

Background: This randomized placebo-controlled clinical trial aimed to evaluate the effect of brushing with caffeinated toothpaste on neurocognitive function of the central nervous system.

Methods: Eighty healthy individuals were randomly assigned to four groups: oral caffeine capsules (100 mg caffeine) as the control, brushing with caffeinated toothpaste (100 mg caffeine) for 2, 3, and 4 min. Cognitive and motor responses were assessed using selective processing speed assessment (Stroop test), short-term memory test, selective attention capacity assessment, and hand-eye coordination test before and after intervention at 10, 30, and 60 min intervals.

Results: Brushing with caffeinated toothpaste was as effective as oral caffeine intake in improving selective attention capacity, selective processing speed, short-term memory, and hand-eye coordination. Despite the higher improvement in the longest duration brushing group in most of the outcomes, the difference did not reach the statistical significance among study groups.

Conclusion: Brushing with caffeinated toothpaste appears to be as effective as oral intake of caffeine in enhance cognitive and motor functions.

Clinical trial registration: https://irct.behdasht.gov.ir/trial/71213, identifier (IRCT20230318057752N2).

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含咖啡因牙膏对中枢神经系统神经认知功能的影响：一项随机安慰剂对照临床试验。

背景：本随机安慰剂对照临床试验旨在评估用含咖啡因牙膏刷牙对中枢神经系统神经认知功能的影响。方法：80名健康个体随机分为四组：口服咖啡因胶囊（100毫克咖啡因）作为对照，用含咖啡因牙膏（100毫克咖啡因）刷牙2、3和4分钟。采用选择性加工速度评估（Stroop测试）、短期记忆测试、选择性注意能力评估和手眼协调测试评估干预前后的认知和运动反应，时间间隔分别为10、30和60 min。结果：含咖啡因牙膏在提高选择性注意力、选择性处理速度、短期记忆和手眼协调能力方面与口服咖啡因牙膏同样有效。尽管时间最长的刷牙组在大多数结果上有更高的改善，但研究组之间的差异没有达到统计学意义。结论：在增强认知和运动功能方面，用含咖啡因的牙膏刷牙似乎和口服咖啡因一样有效。临床试验注册：https://irct.behdasht.gov.ir/trial/71213，标识符（IRCT20230318057752N2）。

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