Immunological biomarkers of aging.

IF 3.4 3区医学 Q2 IMMUNOLOGY

Journal of immunology Pub Date : 2025-05-01 DOI:10.1093/jimmun/vkae036

Fei Wu, Wei-Chieh Mu, Nikola T Markov, Matias Fuentealba, Heather Halaweh, Fiona Senchyna, Max N Manwaring-Mueller, Daniel A Winer, David Furman

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引用次数: 0

Abstract

The immune system has long been recognized for its critical role in the elimination of pathogens and the development of autoimmune diseases, but recent evidence demonstrates that it also contributes to noncommunicable diseases associated with biological aging processes, such as cancer, cardiovascular disease, neurodegeneration, and frailty. This review examines immunological biomarkers of aging, focusing on how the immune system evolves with age and its impact on health and disease. It discusses the historical development of immunological assessments, technological advancements, and the creation of novel biomarkers and models to study immune aging. We also explore the clinical implications of immune aging, such as increased susceptibility to infectious diseases, poor vaccine responses, and a higher incidence of noncommunicable diseases. In summary, we provide a comprehensive overview of current research, highlight the clinical relevance of immune aging, and identify gaps in knowledge that require further investigation.

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衰老的免疫生物标志物。

长期以来，免疫系统一直被认为在消除病原体和自身免疫性疾病的发展中发挥着关键作用，但最近的证据表明，免疫系统也有助于与生物衰老过程相关的非传染性疾病，如癌症、心血管疾病、神经退行性疾病和虚弱。本文综述了衰老的免疫生物标志物，重点关注免疫系统如何随着年龄的增长而进化及其对健康和疾病的影响。它讨论了免疫学评估的历史发展，技术进步，以及研究免疫衰老的新生物标志物和模型的创建。我们还探讨了免疫老化的临床意义，如对传染病的易感性增加、疫苗反应差和非传染性疾病的发病率升高。总之，我们提供了当前研究的全面概述，强调了免疫衰老的临床相关性，并确定了需要进一步研究的知识空白。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of immunology 医学-免疫学

CiteScore

8.20

自引率

2.30%

发文量

495

审稿时长

1 months

期刊介绍： The JI publishes novel, peer-reviewed findings in all areas of experimental immunology, including innate and adaptive immunity, inflammation, host defense, clinical immunology, autoimmunity and more. Special sections include Cutting Edge articles, Brief Reviews and Pillars of Immunology. The JI is published by The American Association of Immunologists (AAI)