Metabolomics Biomarkers for Breast Cancer: An updated perspective.

IF 2.9 3区 医学 Q2 ONCOLOGY
Christina Jane Vellan, Vijayakumar Natesan, Jaime Jacqueline Jayapalan
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引用次数: 0

Abstract

Breast cancer (BC) remains a significant global health concern, emphasising the need for accurate diagnostic and prognostic tools. Metabolomics, the study of small molecules involved in cellular processes, has emerged as a promising approach for identifying BC biomarkers. This review provides an updated overview of metabolomic biomarkers for BC, focusing on early detection, diagnosis, prognosis prediction, and subtype-specific markers. It covers the various sources of biological samples used in biomarker investigations and common methodologies such as liquid chromatography-mass spectrometry and nuclear magnetic resonance. This review also highlights key classes of metabolites, including amino acids, lipids, and carbohydrates, which exhibit consistent alterations in BC patients and are integral to crucial oncogenic pathways, such as energy metabolism, redox balance, immune modulation, and membrane remodeling. Notably, several metabolite panels have demonstrated high sensitivity and specificity, showing promise for effectively stratifying patients according to tumor subtype. Despite the promising potential of metabolomics, challenges remain in standardizing analytical techniques, validating biomarkers, and integrating metabolomics with other omics approaches. Addressing these will be essential for harnessing the full potential of metabolomics in advancing precision oncology for BC.

乳腺癌的代谢组学生物标志物:一个最新的观点。
乳腺癌(BC)仍然是一个重要的全球健康问题,强调需要准确的诊断和预后工具。代谢组学,研究参与细胞过程的小分子,已经成为鉴定BC生物标志物的一种很有前途的方法。这篇综述提供了BC代谢组学生物标志物的最新概述,重点是早期检测、诊断、预后预测和亚型特异性标志物。它涵盖了生物标志物研究中使用的各种生物样品来源和常用方法,如液相色谱-质谱法和核磁共振。这篇综述还强调了代谢产物的关键类别,包括氨基酸、脂质和碳水化合物,它们在BC患者中表现出一致的改变,并且是关键的致癌途径的组成部分,如能量代谢、氧化还原平衡、免疫调节和膜重塑。值得注意的是,一些代谢物小组已经显示出高灵敏度和特异性,显示出根据肿瘤亚型有效地对患者进行分层的希望。尽管代谢组学有很大的潜力,但在标准化分析技术、验证生物标志物以及将代谢组学与其他组学方法整合方面仍然存在挑战。解决这些问题对于充分利用代谢组学在推进BC精确肿瘤学方面的潜力至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clinical breast cancer
Clinical breast cancer 医学-肿瘤学
CiteScore
5.40
自引率
3.20%
发文量
174
审稿时长
48 days
期刊介绍: Clinical Breast Cancer is a peer-reviewed bimonthly journal that publishes original articles describing various aspects of clinical and translational research of breast cancer. Clinical Breast Cancer is devoted to articles on detection, diagnosis, prevention, and treatment of breast cancer. The main emphasis is on recent scientific developments in all areas related to breast cancer. Specific areas of interest include clinical research reports from various therapeutic modalities, cancer genetics, drug sensitivity and resistance, novel imaging, tumor genomics, biomarkers, and chemoprevention strategies.
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