{"title":"Harnessing Stem Cells for Pediatric Respiratory Diseases: Potential and Clinical Translation","authors":"Fatemeh Alizadeh, Sanaz Yasrebinia","doi":"10.1002/cbin.70042","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Pediatric respiratory diseases, ranging from acute infections to chronic lung conditions, pose significant morbidity and mortality risks. Current treatment approaches focus on symptomatic relief rather than regenerative solutions. Stem cell therapy has emerged as a promising alternative due to its potential for immunomodulation, inflammation reduction, and lung tissue repair. Mesenchymal stem cells (MSCs) and induced pluripotent stem cells (iPSCs) have been extensively studied for their regenerative properties, with MSC-derived extracellular vesicles showing potential as a cell-free therapeutic approach. Despite promising preclinical and early clinical findings, challenges such as immune rejection, ethical concerns, and the need for standardized protocols hinder clinical translation. This review examines recent advancements in stem cell therapy for pediatric respiratory diseases, outlining their therapeutic potential, limitations, and future research directions.</p>\n </div>","PeriodicalId":9806,"journal":{"name":"Cell Biology International","volume":"49 8","pages":"929-938"},"PeriodicalIF":3.1000,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Biology International","FirstCategoryId":"99","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cbin.70042","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Pediatric respiratory diseases, ranging from acute infections to chronic lung conditions, pose significant morbidity and mortality risks. Current treatment approaches focus on symptomatic relief rather than regenerative solutions. Stem cell therapy has emerged as a promising alternative due to its potential for immunomodulation, inflammation reduction, and lung tissue repair. Mesenchymal stem cells (MSCs) and induced pluripotent stem cells (iPSCs) have been extensively studied for their regenerative properties, with MSC-derived extracellular vesicles showing potential as a cell-free therapeutic approach. Despite promising preclinical and early clinical findings, challenges such as immune rejection, ethical concerns, and the need for standardized protocols hinder clinical translation. This review examines recent advancements in stem cell therapy for pediatric respiratory diseases, outlining their therapeutic potential, limitations, and future research directions.
期刊介绍：
Each month, the journal publishes easy-to-assimilate, up-to-the minute reports of experimental findings by researchers using a wide range of the latest techniques. Promoting the aims of cell biologists worldwide, papers reporting on structure and function - especially where they relate to the physiology of the whole cell - are strongly encouraged. Molecular biology is welcome, as long as articles report findings that are seen in the wider context of cell biology. In covering all areas of the cell, the journal is both appealing and accessible to a broad audience. Authors whose papers do not appeal to cell biologists in general because their topic is too specialized (e.g. infectious microbes, protozoology) are recommended to send them to more relevant journals. Papers reporting whole animal studies or work more suited to a medical journal, e.g. histopathological studies or clinical immunology, are unlikely to be accepted, unless they are fully focused on some important cellular aspect.
These last remarks extend particularly to papers on cancer. Unless firmly based on some deeper cellular or molecular biological principle, papers that are highly specialized in this field, with limited appeal to cell biologists at large, should be directed towards journals devoted to cancer, there being very many from which to choose.
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