Effects of the modified "Yijing Fang" on semen quality and reproductive hormones in male yaks with kidney yang deficiency: a focus on mitochondrial apoptosis pathways.

IF 1.6 4区 农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE
Animal Reproduction Pub Date : 2025-05-26 eCollection Date: 2025-01-01 DOI:10.1590/1984-3143-AR2024-0139
Panfeng Chang, Hua Wang
{"title":"Effects of the modified \"Yijing Fang\" on semen quality and reproductive hormones in male yaks with kidney yang deficiency: a focus on mitochondrial apoptosis pathways.","authors":"Panfeng Chang, Hua Wang","doi":"10.1590/1984-3143-AR2024-0139","DOIUrl":null,"url":null,"abstract":"<p><p>Intensive semen collection often leads to \"kidney yang deficiency\" in male yaks, with symptoms like lethargy and poor semen quality. Our modified \"Yijing Fang\" was tested. Eight 3 - 6-year-old male yaks with this condition were split into treatment and negative control groups; four healthy yaks were a blank control. The treated yaks got the formula in feed for 5 days, then a 20-day break, repeating 3 times over 65 days. Semen was collected, and cAMP, cGMP, T/E2 levels, and mitochondrial apoptosis factors were analyzed. Results showed the formula boosted semen quality. cAMP and testosterone rose (p < 0.01), cGMP and estradiol fell (p < 0.01), cAMP/cGMP and T/E2 ratios climbed (p < 0.01). Bcl-2 upregulated, Bax, Cyt-C, and Caspase-3 downregulated (p < 0.01). In conclusion, the modified \"Yijing Fang\" is effective for yak reproduction, enhancing hormone secretion and reducing sperm apoptosis. Long-term studies are needed.</p>","PeriodicalId":7889,"journal":{"name":"Animal Reproduction","volume":"22 2","pages":"e20240139"},"PeriodicalIF":1.6000,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121852/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Animal Reproduction","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1590/1984-3143-AR2024-0139","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"AGRICULTURE, DAIRY & ANIMAL SCIENCE","Score":null,"Total":0}
引用次数: 0

Abstract

Intensive semen collection often leads to "kidney yang deficiency" in male yaks, with symptoms like lethargy and poor semen quality. Our modified "Yijing Fang" was tested. Eight 3 - 6-year-old male yaks with this condition were split into treatment and negative control groups; four healthy yaks were a blank control. The treated yaks got the formula in feed for 5 days, then a 20-day break, repeating 3 times over 65 days. Semen was collected, and cAMP, cGMP, T/E2 levels, and mitochondrial apoptosis factors were analyzed. Results showed the formula boosted semen quality. cAMP and testosterone rose (p < 0.01), cGMP and estradiol fell (p < 0.01), cAMP/cGMP and T/E2 ratios climbed (p < 0.01). Bcl-2 upregulated, Bax, Cyt-C, and Caspase-3 downregulated (p < 0.01). In conclusion, the modified "Yijing Fang" is effective for yak reproduction, enhancing hormone secretion and reducing sperm apoptosis. Long-term studies are needed.

益精方对肾阳虚雄性牦牛精液质量及生殖激素的影响——以线粒体凋亡途径为重点
大量采集精液常导致公牦牛出现“肾阳虚”,表现为嗜睡、精液质量差等症状。我们改良的“易经坊”进行了测试。将8头3 ~ 6岁雄性牦牛分为治疗组和阴性对照组;4头健康牦牛作为空白对照。试验牦牛先饲喂5 d,然后休息20 d,重复3次,共65 d。收集精液,分析cAMP、cGMP、T/E2水平和线粒体凋亡因子。结果表明,该配方提高了精液质量。cAMP和睾酮升高(p < 0.01), cGMP和雌二醇下降(p < 0.01), cAMP/cGMP和T/E2比值升高(p < 0.01)。Bcl-2上调,Bax、Cyt-C、Caspase-3下调(p < 0.01)。由此可见,经改良的“益精方”具有促进牦牛繁殖、促进激素分泌、减少精子凋亡的作用。需要长期研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Animal Reproduction
Animal Reproduction AGRICULTURE, DAIRY & ANIMAL SCIENCE-
CiteScore
2.30
自引率
11.80%
发文量
49
审稿时长
70 days
期刊介绍: Animal Reproduction (AR) publishes original scientific papers and invited literature reviews, in the form of Basic Research, Biotechnology, Applied Research and Review Articles, with the goal of contributing to a better understanding of phenomena related to animal reproduction. The scope of the journal applies to students, researchers and practitioners in the fields of veterinary, biology and animal science, also being of interest to practitioners of human medicine. Animal Reproduction Journal is the official organ of the Brazilian College of Animal Reproduction in Brazil.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信