Yao Ni, Juanmei Li, Zitian Tang, Youqian Zhang, Yanyan Feng
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引用次数: 0
Abstract
Background: Rapid changes in attitudes, legality, and patterns of cannabis use (CU) underscore the importance of understanding its impact on mental health. Although links between CU and personality disorders (PDs) are documented, their causality remains uncertain.
Methods: Employing Genome-Wide Association Studies (GWAS) data, this study investigated the causal relationship between cannabis use disorder (CUD) and lifetime cannabis use (LCU) with 9 types of PD risk through Mendelian randomization (MR) analysis. The primary method was the inverse variance weighted (IVW) method, supplemented by multivariable MR to assess direct effects independent of mental, social, and substance use factors, and mediation MR to explore mediating factors.
Results: Corrections for the false discovery rate revealed significant causal associations between CUD and an increased risk of emotionally unstable PD (EUPD; ORIVW = 1.228, 95% CI 1.069-1.411), overall PD (ORIVW = 1.186, 95% CI 1.065-1.321), and schizoid PD (SPD; ORIVW = 1.644, 95% CI 1.131-2.390). Mediation analysis identified schizophrenia (SCZ), major depressive disorder (MDD), neuroticism, and smoking initiation (SmkInit) as shared mediating factors between CUD and both EUPD and overall PD, with an additional mediating factor, household income (HI), specific to the CUD-to-overall PD pathway. In contrast, no mediating factors were found between CUD and SPD. Notably, a bidirectional causal relationship was observed between overall PD and CUD (ORIVW = 1.399, 95% CI 1.033-1.895). Suggestive evidence indicated a causal link between lifetime cannabis use (LCU) and overall PD risk (ORIVW = 1.074, 95% CI 1.008-1.146).
Conclusion: This study offers new insights into the potential impact of CU on the development and progression of various PDs, laying the groundwork for targeted interventions to mitigate its effects on mental health.
期刊介绍：
Frontiers in Psychiatry publishes rigorously peer-reviewed research across a wide spectrum of translational, basic and clinical research. Field Chief Editor Stefan Borgwardt at the University of Basel is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
The journal''s mission is to use translational approaches to improve therapeutic options for mental illness and consequently to improve patient treatment outcomes.
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