A neoflavonoid from the stems and leaves of Paris tengchongensis and its inhibitory activity against vascular calcification

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-05-30 DOI:10.1016/j.phytol.2025.102992

Yan Chen , Shicheng Wu , Xuan Chen , Lin Zhang , Xirong Chen , Ya Zhu

引用次数: 0

Abstract

A previously undescribed neoflavonoid (1), as well as five known compounds including Kaempferol (2), isorhamnetin (3), quercetin (4), coumestrol (5), dalbergin (6) were isolated from the stems and leaves of Paris tengchongensis. Focusing on vascular protective activity, we found it can inhibit alkaline phosphatase (ALP) activity and reduce the level of advanced glycation end products (AGEs)in Human Aortic Smooth Muscle Cells (HASMCs).

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腾春巴黎茎叶新黄酮类化合物及其对血管钙化的抑制作用

从腾chongensis的茎和叶中分离得到了一种新类黄酮(1)，以及山奈酚(2)、异鼠李素(3)、槲皮素(4)、库梅醇(5)、黄檀素(6)等5种已知化合物。在血管保护活性方面，我们发现它可以抑制人主动脉平滑肌细胞（HASMCs）的碱性磷酸酶（ALP）活性，降低晚期糖基化终产物（AGEs）的水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.