Intelligent Sensing Switches in Drug Delivery Systems: Mechanisms, Material Selection, and Future Perspectives

IF 3.9 3区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of biomedical materials research. Part A Pub Date : 2025-05-30 DOI:10.1002/jbm.a.37938

Fuyu Chen, Heng Li, Chengdong Zhen, Guimei Lin, Bingtao Tang, Yanbin Shi, Li Wang, Jinwei Qiao, Xuelin Li

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引用次数: 0

Abstract

The intelligence and controllability of drug delivery systems (DDS) are crucial for enhancing therapeutic efficacy and minimizing side effects. Among these, DDS responsive switches play a pivotal role in precisely regulating the timing and spatial distribution of drug release in response to specific physiological environments within the body or external stimuli. Based on the origin of stimuli, they can be categorized into endogenous and exogenous stimuli. This paper reviews various types of stimulus-responsive switches, including dual-stimulus responsive switches, and elaborates on the drug release mechanisms of each intelligent switch. It summarizes the advantages and limitations of different stimulus-responsive systems, highlights the properties of commonly used temperature-sensitive materials, and discusses the applications of popular nano-engineered materials in pH and electromagnetic-responsive switches. Finally, the paper provides an outlook on the future of DDS, focusing on achieving more precise control, as well as ensuring clinical stability and reliability.

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药物传递系统中的智能传感开关：机制、材料选择和未来展望

药物传递系统（DDS）的智能化和可控性对于提高治疗效果和减少副作用至关重要。其中，DDS响应开关在精确调节药物释放的时间和空间分布方面发挥关键作用，以响应体内特定的生理环境或外部刺激。根据刺激的来源可分为内源性刺激和外源性刺激。本文综述了包括双刺激反应开关在内的各类刺激反应开关，并详细阐述了每种智能开关的药物释放机制。总结了不同的刺激响应系统的优点和局限性，重点介绍了常用的温度敏感材料的特性，并讨论了流行的纳米工程材料在pH和电磁响应开关中的应用。最后，展望了DDS的未来，重点是实现更精确的控制，以及确保临床的稳定性和可靠性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of biomedical materials research. Part A 工程技术-材料科学：生物材料

CiteScore

10.40

自引率

2.00%

发文量

135

审稿时长

3.6 months

期刊介绍： The Journal of Biomedical Materials Research Part A is an international, interdisciplinary, English-language publication of original contributions concerning studies of the preparation, performance, and evaluation of biomaterials; the chemical, physical, toxicological, and mechanical behavior of materials in physiological environments; and the response of blood and tissues to biomaterials. The Journal publishes peer-reviewed articles on all relevant biomaterial topics including the science and technology of alloys,polymers, ceramics, and reprocessed animal and human tissues in surgery,dentistry, artificial organs, and other medical devices. The Journal also publishes articles in interdisciplinary areas such as tissue engineering and controlled release technology where biomaterials play a significant role in the performance of the medical device. The Journal of Biomedical Materials Research is the official journal of the Society for Biomaterials (USA), the Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Articles are welcomed from all scientists. Membership in the Society for Biomaterials is not a prerequisite for submission.