Life's Crucial 9 and its influence on frailty and survival in patients with cancer: Insights from NHANES

IF 3 3区医学 Q3 GERIATRICS & GERONTOLOGY

Journal of geriatric oncology Pub Date : 2025-05-30 DOI:10.1016/j.jgo.2025.102276

Zheling Chen , Xiuxiu Qiu , Qi Gao

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引用次数: 0

Abstract

Introduction

This study aims to examine the effect of Life's Crucial 9 (LC9), a comprehensive health measure, on frailty status and its association with all-cause, cancer-related, and non-cancer-related mortality in patients with cancer.

Materials and Methods

A prospective cohort study was conducted with 2466 patients with cancer aged 20 years or older (weighted population: 16,222,181) from the National Health and Nutrition Examination Survey (NHANES) between 2005 and 2018. The LC9 score was calculated by averaging the Life's Essential 8 (LE8) and depression scores, which reflect psychological well-being. Multivariable logistic regression models were used to examine the relationship between LC9 and frailty in patients with cancer, while Cox proportional hazards models evaluated the associations between LC9 and all-cause, cancer-specific, and non-cancer mortality.

Results

At baseline, 664 deaths were recorded among the 2466 patients with cancer, including 229 from cancer, 138 from heart disease, and 297 from other causes. Higher LC9 scores were linked to a lower risk of frailty and reduced hazard ratios for all-cause and non-cancer mortality, but not for cancer-specific mortality, compared to those with lower scores. Kaplan-Meier survival curves stratified by LC9 quartiles showed that participants in the highest quartile (Q4) had significantly lower risks of death from all causes (P < 0.001), cancer-specific causes (P = 0.01), and non-cancer causes (P < 0.001).

Discussion

In patients with cancer in the United States, higher LC9 scores were independently associated with reduced risks of frailty, all-cause mortality, and non-cancer-related mortality. This health measure may serve as an effective secondary prevention strategy to mitigate mortality in this population.

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生命的关键及其对癌症患者虚弱和生存的影响：来自NHANES的见解

本研究旨在探讨生命关键9 （Life's critical 9, LC9）这一综合健康指标对癌症患者虚弱状态的影响及其与全因、癌症相关和非癌症相关死亡率的关系。材料与方法在2005年至2018年期间，对2466名20岁及以上的癌症患者（加权人群：16,222,181）进行了一项前瞻性队列研究。LC9得分是通过平均生活基本8 （LE8）和抑郁得分来计算的，这反映了心理健康状况。使用多变量logistic回归模型来检验LC9与癌症患者虚弱之间的关系，而Cox比例风险模型评估LC9与全因、癌症特异性和非癌症死亡率之间的关系。结果基线时，2466例癌症患者中有664例死亡，其中229例死于癌症，138例死于心脏病，297例死于其他原因。与得分较低的人相比，LC9得分较高的人身体虚弱的风险较低，全因死亡率和非癌症死亡率的风险比较低，但与癌症特异性死亡率无关。按LC9四分位数分层的Kaplan-Meier生存曲线显示，处于最高四分位数（Q4）的参与者因各种原因死亡的风险显著降低(P <；0.001)，癌症特异性原因（P = 0.01）和非癌症原因(P <；0.001)。在美国的癌症患者中，较高的LC9评分与虚弱、全因死亡率和非癌症相关死亡率的风险降低独立相关。这一卫生措施可作为一种有效的二级预防策略，以降低这一人群的死亡率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of geriatric oncology ONCOLOGY-GERIATRICS & GERONTOLOGY

CiteScore

5.30

自引率

10.00%

发文量

379

审稿时长

80 days

期刊介绍： The Journal of Geriatric Oncology is an international, multidisciplinary journal which is focused on advancing research in the treatment and survivorship issues of older adults with cancer, as well as literature relevant to education and policy development in geriatric oncology. The journal welcomes the submission of manuscripts in the following categories: • Original research articles • Review articles • Clinical trials • Education and training articles • Short communications • Perspectives • Meeting reports • Letters to the Editor.