Cobalt doped Fe3O4 nanoparticles with improved magnetic anisotropy and enhanced hyperthermic efficiency

IF 5.1 2区 材料科学 Q1 MATERIALS SCIENCE, CERAMICS
Rahulgorky Sahayaraj , Karolinekersin Enoch , Sudhanshu Shekar Pati , Anbumozhi Angayarkanni Somasundaram
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Abstract

Magnetite nanoparticles are promising candidates for Magnetic Fluid Hyperthermia in cancer treatment, exploiting alternating magnetic fields to selectively generate heat in tumor tissues. However, achieving optimal hyperthermic efficiency within the clinical therapeutic window remains challenging due to the need for precise tuning of their magnetic and physical properties. To address this, we investigated the effects of doping Fe3O4 nanoparticles with varying concentrations of cobalt to enhance their magnetic properties, such as anisotropy constant and saturation magnetization. We synthesized a series of cobalt-doped Fe3O4 nanoparticles and characterized their physical and magnetic properties using X-ray diffraction, Fourier Transform Infrared spectroscopy, High-Resolution Transmission Electron Microscopy, and Vibrating Sample Magnetometry. Our results show that cobalt doping increases the coercivity of SPIONs, with values rising from 21.98 Oe at 2 wt% doping to 57.54 Oe at 5 wt% doping. However, this increase remains within a range that does not alter the superparamagnetic nature of the nanoparticles. The 2 % cobalt-doped Fe3O4 achieved a SAR of 25.87 W/g and an ESAR of 0.81 nH m2/kg, marking a substantial improvement over undoped Fe3O4. However, higher cobalt concentrations reduced hyperthermic efficiency. These findings suggest that low-level cobalt doping is an effective strategy to enhance the hyperthermic performance of Fe3O4 nanoparticles by improving the anisotropy and addressing the current limitations in magnetic hyperthermia applications.
钴掺杂Fe3O4纳米粒子具有改善磁各向异性和提高热效率的特性
磁铁矿纳米颗粒利用交变磁场在肿瘤组织中选择性地产生热量,是癌症治疗中磁流体热疗的有希望的候选者。然而,由于需要精确调整其磁性和物理特性,在临床治疗窗口内实现最佳的热疗效率仍然具有挑战性。为了解决这个问题,我们研究了掺杂不同浓度钴的Fe3O4纳米粒子对其磁性的影响,如各向异性常数和饱和磁化。我们合成了一系列掺杂钴的Fe3O4纳米粒子,并利用x射线衍射、傅里叶变换红外光谱、高分辨率透射电子显微镜和振动样品磁强计对其物理和磁性能进行了表征。结果表明,钴的掺杂提高了SPIONs的矫顽力,其矫顽力从掺杂2wt %时的21.98 Oe增加到掺杂5wt %时的57.54 Oe。然而,这种增加仍然在一个范围内,不会改变纳米粒子的超顺磁性。掺2%钴的Fe3O4的SAR为25.87 W/g, ESAR为0.81 nH m2/kg,比未掺Fe3O4有了很大的提高。然而,较高的钴浓度降低了热效率。这些发现表明,低水平的钴掺杂是一种有效的策略,可以通过改善Fe3O4纳米颗粒的各向异性和解决目前在磁热疗应用中的局限性来增强Fe3O4纳米颗粒的热性能。
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来源期刊
Ceramics International
Ceramics International 工程技术-材料科学:硅酸盐
CiteScore
9.40
自引率
15.40%
发文量
4558
审稿时长
25 days
期刊介绍: Ceramics International covers the science of advanced ceramic materials. The journal encourages contributions that demonstrate how an understanding of the basic chemical and physical phenomena may direct materials design and stimulate ideas for new or improved processing techniques, in order to obtain materials with desired structural features and properties. Ceramics International covers oxide and non-oxide ceramics, functional glasses, glass ceramics, amorphous inorganic non-metallic materials (and their combinations with metal and organic materials), in the form of particulates, dense or porous bodies, thin/thick films and laminated, graded and composite structures. Process related topics such as ceramic-ceramic joints or joining ceramics with dissimilar materials, as well as surface finishing and conditioning are also covered. Besides traditional processing techniques, manufacturing routes of interest include innovative procedures benefiting from externally applied stresses, electromagnetic fields and energetic beams, as well as top-down and self-assembly nanotechnology approaches. In addition, the journal welcomes submissions on bio-inspired and bio-enabled materials designs, experimentally validated multi scale modelling and simulation for materials design, and the use of the most advanced chemical and physical characterization techniques of structure, properties and behaviour. Technologically relevant low-dimensional systems are a particular focus of Ceramics International. These include 0, 1 and 2-D nanomaterials (also covering CNTs, graphene and related materials, and diamond-like carbons), their nanocomposites, as well as nano-hybrids and hierarchical multifunctional nanostructures that might integrate molecular, biological and electronic components.
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