{"title":"Cobalt doped Fe3O4 nanoparticles with improved magnetic anisotropy and enhanced hyperthermic efficiency","authors":"Rahulgorky Sahayaraj , Karolinekersin Enoch , Sudhanshu Shekar Pati , Anbumozhi Angayarkanni Somasundaram","doi":"10.1016/j.ceramint.2025.02.245","DOIUrl":null,"url":null,"abstract":"<div><div>Magnetite nanoparticles are promising candidates for Magnetic Fluid Hyperthermia in cancer treatment, exploiting alternating magnetic fields to selectively generate heat in tumor tissues. However, achieving optimal hyperthermic efficiency within the clinical therapeutic window remains challenging due to the need for precise tuning of their magnetic and physical properties. To address this, we investigated the effects of doping Fe<sub>3</sub>O<sub>4</sub> nanoparticles with varying concentrations of cobalt to enhance their magnetic properties, such as anisotropy constant and saturation magnetization. We synthesized a series of cobalt-doped Fe<sub>3</sub>O<sub>4</sub> nanoparticles and characterized their physical and magnetic properties using X-ray diffraction, Fourier Transform Infrared spectroscopy, High-Resolution Transmission Electron Microscopy, and Vibrating Sample Magnetometry. Our results show that cobalt doping increases the coercivity of SPIONs, with values rising from 21.98 Oe at 2 wt% doping to 57.54 Oe at 5 wt% doping. However, this increase remains within a range that does not alter the superparamagnetic nature of the nanoparticles. The 2 % cobalt-doped Fe<sub>3</sub>O<sub>4</sub> achieved a SAR of 25.87 W/g and an ESAR of 0.81 nH m<sup>2</sup>/kg, marking a substantial improvement over undoped Fe<sub>3</sub>O<sub>4.</sub> However, higher cobalt concentrations reduced hyperthermic efficiency. These findings suggest that low-level cobalt doping is an effective strategy to enhance the hyperthermic performance of Fe<sub>3</sub>O<sub>4</sub> nanoparticles by improving the anisotropy and addressing the current limitations in magnetic hyperthermia applications.</div></div>","PeriodicalId":267,"journal":{"name":"Ceramics International","volume":"51 15","pages":"Pages 20786-20797"},"PeriodicalIF":5.1000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ceramics International","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0272884225009289","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, CERAMICS","Score":null,"Total":0}
引用次数: 0
Abstract
Magnetite nanoparticles are promising candidates for Magnetic Fluid Hyperthermia in cancer treatment, exploiting alternating magnetic fields to selectively generate heat in tumor tissues. However, achieving optimal hyperthermic efficiency within the clinical therapeutic window remains challenging due to the need for precise tuning of their magnetic and physical properties. To address this, we investigated the effects of doping Fe3O4 nanoparticles with varying concentrations of cobalt to enhance their magnetic properties, such as anisotropy constant and saturation magnetization. We synthesized a series of cobalt-doped Fe3O4 nanoparticles and characterized their physical and magnetic properties using X-ray diffraction, Fourier Transform Infrared spectroscopy, High-Resolution Transmission Electron Microscopy, and Vibrating Sample Magnetometry. Our results show that cobalt doping increases the coercivity of SPIONs, with values rising from 21.98 Oe at 2 wt% doping to 57.54 Oe at 5 wt% doping. However, this increase remains within a range that does not alter the superparamagnetic nature of the nanoparticles. The 2 % cobalt-doped Fe3O4 achieved a SAR of 25.87 W/g and an ESAR of 0.81 nH m2/kg, marking a substantial improvement over undoped Fe3O4. However, higher cobalt concentrations reduced hyperthermic efficiency. These findings suggest that low-level cobalt doping is an effective strategy to enhance the hyperthermic performance of Fe3O4 nanoparticles by improving the anisotropy and addressing the current limitations in magnetic hyperthermia applications.
期刊介绍:
Ceramics International covers the science of advanced ceramic materials. The journal encourages contributions that demonstrate how an understanding of the basic chemical and physical phenomena may direct materials design and stimulate ideas for new or improved processing techniques, in order to obtain materials with desired structural features and properties.
Ceramics International covers oxide and non-oxide ceramics, functional glasses, glass ceramics, amorphous inorganic non-metallic materials (and their combinations with metal and organic materials), in the form of particulates, dense or porous bodies, thin/thick films and laminated, graded and composite structures. Process related topics such as ceramic-ceramic joints or joining ceramics with dissimilar materials, as well as surface finishing and conditioning are also covered. Besides traditional processing techniques, manufacturing routes of interest include innovative procedures benefiting from externally applied stresses, electromagnetic fields and energetic beams, as well as top-down and self-assembly nanotechnology approaches. In addition, the journal welcomes submissions on bio-inspired and bio-enabled materials designs, experimentally validated multi scale modelling and simulation for materials design, and the use of the most advanced chemical and physical characterization techniques of structure, properties and behaviour.
Technologically relevant low-dimensional systems are a particular focus of Ceramics International. These include 0, 1 and 2-D nanomaterials (also covering CNTs, graphene and related materials, and diamond-like carbons), their nanocomposites, as well as nano-hybrids and hierarchical multifunctional nanostructures that might integrate molecular, biological and electronic components.