Malaria vaccine acceptance and associated factors in cameroon: A nationwide cross-sectional survey

IF 4.5 3区医学 Q2 IMMUNOLOGY

Vaccine Pub Date : 2025-05-30 DOI:10.1016/j.vaccine.2025.127323

Andreas Ateke Njoh MD, MSc, PhD(c) , Jerome Nyhalah Dinga PhD , Eugene Justine Kongnyuy MD, PhD , Tchokfe Shalom Ndoula MD, MPh , Adidja Amani MD, MPh, PhD(c) , Ibrahima Madaina MSc , Muluh Ngwe Sonnet Ticha MD , Messang Blandine Abizou MD , Yauba Saidu MD, PhD , Hassan Ben Bachir MD, MPh , Laurent Cleenewerck de Kiev MES, MPH, PhD

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引用次数: 0

Abstract

Introduction

Malaria is a life-threatening mosquito-borne disease. This significant public health problem disproportionately affects people in Africa. Despite investments in existing vector control and curative treatments, malaria remains the first infant-child morbidity and mortality cause, with 11,000 annual deaths in Cameroon. However, there are effective vaccines against the disease. So, this study sought to evaluate vaccine acceptance and related factors to guide the vaccine rollout.

Method

This nationwide cross-sectional survey collected data from December 2023 to January 2024 using an online and in-person questionnaire. The chi-square test identified the malaria vaccine acceptance elements, and multiple logistic regression depicted factors linked to vaccine acceptance. SPSS enabled analysis, and a p-value <0.05 was considered significant. Microsoft Excel 365 eased the elaboration of charts and tables.

Result

Data from 2025 participants indicated a 91 % malaria vaccine acceptance. This rate varied from 78 % in the Littoral to 94 % in the Far North and South West regions. Factors that favor vaccine acceptance include a history of severe malaria (OR = 1.4, 95 %CI: 1.0–1.8, p = 0.03), awareness of the availability of the malaria vaccine for infants (OR = 1.4, 95 %CI: 1.0–2.0, p = 0.03), and working in the vaccination service (OR = 3.8, 95 %CI: 2.7–5.3, p < 0.01). Elements reported for vaccine hesitancy include fear of unsafe and negative rumors about the vaccine.

Conclusion

People in Cameroon are willing to get their children vaccinated against malaria. However, following regional acceptance disparities and identified hesitancy points, it is crucial to reinforce communication to address population groups, doubts, and rumors about vaccines to ensure optimal uptake in the country's regions during the malaria vaccine rollout.

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喀麦隆疟疾疫苗接受程度及相关因素：一项全国性横断面调查

疟疾是一种危及生命的蚊媒疾病。这一重大公共卫生问题对非洲人民的影响尤为严重。尽管对现有的病媒控制和治疗进行了投资，但疟疾仍然是婴儿发病和死亡的首要原因，喀麦隆每年有11 000人死亡。然而，有有效的疫苗可以预防这种疾病。因此，本研究旨在评估疫苗接受度及相关因素，以指导疫苗的推广。方法本研究于2023年12月至2024年1月期间，采用在线问卷和面对面问卷的方式，在全国范围内进行横断面调查。卡方检验确定了疟疾疫苗接受因素，多元逻辑回归描述了与疫苗接受相关的因素。SPSS支持分析，p值为0.05被认为是显著的。微软Excel 365简化了图表和表格的制作。结果来自2025名参与者的数据表明，91%的人接受疟疾疫苗。这一比率从沿海地区的78%到远北和西南地区的94%不等。有利于接受疫苗的因素包括严重疟疾史（OR = 1.4, 95% CI: 1.0-1.8, p = 0.03），对婴儿可获得疟疾疫苗的认识（OR = 1.4, 95% CI: 1.0-2.0, p = 0.03），以及在疫苗接种服务部门工作(OR = 3.8, 95% CI: 2.7-5.3, p <；0.01)。据报告，对疫苗犹豫不决的因素包括对疫苗不安全和负面谣言的恐惧。结论喀麦隆民众愿意为孩子接种疟疾疫苗。然而，由于存在区域接受差异和已确定的犹豫点，必须加强沟通，以解决人口群体、对疫苗的疑虑和谣言，以确保在疟疾疫苗推广期间该国各地区获得最佳接受。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Vaccine 医学-免疫学

CiteScore

8.70

自引率

5.50%

发文量

992

审稿时长

131 days

期刊介绍： Vaccine is unique in publishing the highest quality science across all disciplines relevant to the field of vaccinology - all original article submissions across basic and clinical research, vaccine manufacturing, history, public policy, behavioral science and ethics, social sciences, safety, and many other related areas are welcomed. The submission categories as given in the Guide for Authors indicate where we receive the most papers. Papers outside these major areas are also welcome and authors are encouraged to contact us with specific questions.