Increased risk of cardiovascular disease in women with endometriosis: A systematic review and meta-analysis

IF 2.1 4区医学 Q2 OBSTETRICS & GYNECOLOGY

European journal of obstetrics, gynecology, and reproductive biology Pub Date : 2025-05-23 DOI:10.1016/j.ejogrb.2025.114081

Muhammad Saad , Ifrah Ansari , Zainab Siddiqua Ibrahim , Ruqiat Masooma Batool , Syed Ibad Ahsan , Muhammad Sameer Arshad , Peter Collins , Raheel Ahmed

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Abstract

Background

The association between endometriosis and cardiovascular disease remains poorly understood. This study conducted a meta-analysis to evaluate the risk of adverse cardiovascular outcomes in women with endometriosis compared to those without the condition.

Methods

A comprehensive search of online databases was performed up to November 2024 to identify studies comparing adverse cardiovascular outcomes in women with and without endometriosis. A random-effects model was employed for the meta-analysis to calculate hazard ratios (HRs) with 95% confidence intervals (CIs).

Results

The meta-analysis included seven studies encompassing a total of 1,407,875 participants. Women with endometriosis demonstrated a significantly increased risk of cerebrovascular disease (HR: 1.19, 95 % CI: 1.13–1.24, p < 0.00001) and ischemic heart disease (HR: 1.35, 95 % CI: 1.32–1.39, p < 0.00001). Additionally, the risk of major adverse cardiovascular events (HR: 1.15, 95 % CI: 1.13–1.19, p < 0.00001) and arrhythmias (HR: 1.21, 95 % CI: 1.17–1.25, p < 0.00001) was significantly elevated. However, no significant associations were observed for heart failure or all-cause mortality.

Conclusion

This meta-analysis indicates that women with endometriosis are at heightened risk for several cardiovascular conditions. These findings underscore the need for robust prospective studies to validate these associations and to explore underlying mechanisms.

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子宫内膜异位症女性心血管疾病风险增加：系统回顾和荟萃分析

背景子宫内膜异位症与心血管疾病之间的关系仍然知之甚少。本研究进行了一项荟萃分析，以评估子宫内膜异位症女性与无子宫内膜异位症女性发生不良心血管结局的风险。方法对截止到2024年11月的在线数据库进行全面检索，以确定比较子宫内膜异位症和非子宫内膜异位症女性不良心血管结局的研究。meta分析采用随机效应模型，以95%置信区间（ci）计算风险比（hr）。荟萃分析包括7项研究，共1407875名参与者。子宫内膜异位症患者发生脑血管疾病的风险显著增加(HR: 1.19, 95% CI: 1.13-1.24, p <；0.00001)和缺血性心脏病(HR: 1.35, 95% CI: 1.32-1.39, p <；0.00001)。此外，主要不良心血管事件的风险(HR: 1.15, 95% CI: 1.13-1.19, p <；0.00001)和心律失常(HR: 1.21, 95% CI: 1.17-1.25, p <；0.00001)显著升高。然而，没有观察到心脏衰竭或全因死亡率的显著相关性。结论：该荟萃分析表明，子宫内膜异位症的女性患几种心血管疾病的风险更高。这些发现强调需要进行强有力的前瞻性研究来验证这些关联并探索潜在的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European journal of obstetrics, gynecology, and reproductive biology 医学-妇产科学

CiteScore

4.60

自引率

3.80%

发文量

898

审稿时长

8.3 weeks

期刊介绍： The European Journal of Obstetrics & Gynecology and Reproductive Biology is the leading general clinical journal covering the continent. It publishes peer reviewed original research articles, as well as a wide range of news, book reviews, biographical, historical and educational articles and a lively correspondence section. Fields covered include obstetrics, prenatal diagnosis, maternal-fetal medicine, perinatology, general gynecology, gynecologic oncology, uro-gynecology, reproductive medicine, infertility, reproductive endocrinology, sexual medicine and reproductive ethics. The European Journal of Obstetrics & Gynecology and Reproductive Biology provides a forum for scientific and clinical professional communication in obstetrics and gynecology throughout Europe and the world.