Effect of Fe-Mg co-incorporation on the mechanical properties, biodegradation, osteogenesis and immunoregulation in vitro of 3D printed biphasic calcium phosphate bioceramics
Dong Dong , Haijun Su , Jian Xing , Xiang Li , Zhonglin Shen , Hao Jiang , Minghui Yu , Min Guo , Zhuo Zhang , Pengfei Wang
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引用次数: 0
Abstract
Introducing functional elements to biomaterials is a widely recognized effective strategy to enhance their biological properties. In this study, iron (Fe) and magnesium oxide (MgO) were co-incorporated into biphasic calcium phosphate (BCP) bioceramics fabricated by vat polymerization (VPP) technique to regulate the microstructure, mechanical properties, biodegradation, biocompatibility and bioactivity. Our results showed the decrease of curing depth of BCP slurries was mainly owing to the addition of Fe. The incorporation of Fe increased the grain size, but co-incorporation of MgO decreased the grain size again. The co-incorporation of Fe and MgO increased the porosity of BCP scaffolds, and decreased their compressive strength. However, the single addition of Fe increased the compressive strength. The introducing of Fe suppressed the degradation of BCP, but Fe-Mg co-doped BCP showed faster degradation than BCP with Fe alone. However, the addition of MgO diminished the formation of bioactive apatite. In vitro, Fe-Mg co-doped BCP showed good biocompatibility, and 0.5Fe2Mg-BCP showed the best capacity on promoting osteogenic differentiation of MC3T3-E1. Fe-Mg co-doped BCP obviously regulated the RAW 264.7 polarization, inflammatory and anti-inflammatory activities which are favor of osteogenesis. This work demonstrated that the co-doping of Fe2+ and Mg2+ was favor of promoting osteogenic differentiation and Fe-Mg co-doped BCP was a promising biomaterial for bone regeneration.
期刊介绍:
Ceramics International covers the science of advanced ceramic materials. The journal encourages contributions that demonstrate how an understanding of the basic chemical and physical phenomena may direct materials design and stimulate ideas for new or improved processing techniques, in order to obtain materials with desired structural features and properties.
Ceramics International covers oxide and non-oxide ceramics, functional glasses, glass ceramics, amorphous inorganic non-metallic materials (and their combinations with metal and organic materials), in the form of particulates, dense or porous bodies, thin/thick films and laminated, graded and composite structures. Process related topics such as ceramic-ceramic joints or joining ceramics with dissimilar materials, as well as surface finishing and conditioning are also covered. Besides traditional processing techniques, manufacturing routes of interest include innovative procedures benefiting from externally applied stresses, electromagnetic fields and energetic beams, as well as top-down and self-assembly nanotechnology approaches. In addition, the journal welcomes submissions on bio-inspired and bio-enabled materials designs, experimentally validated multi scale modelling and simulation for materials design, and the use of the most advanced chemical and physical characterization techniques of structure, properties and behaviour.
Technologically relevant low-dimensional systems are a particular focus of Ceramics International. These include 0, 1 and 2-D nanomaterials (also covering CNTs, graphene and related materials, and diamond-like carbons), their nanocomposites, as well as nano-hybrids and hierarchical multifunctional nanostructures that might integrate molecular, biological and electronic components.