Effect of Fe-Mg co-incorporation on the mechanical properties, biodegradation, osteogenesis and immunoregulation in vitro of 3D printed biphasic calcium phosphate bioceramics

IF 5.1 2区 材料科学 Q1 MATERIALS SCIENCE, CERAMICS
Dong Dong , Haijun Su , Jian Xing , Xiang Li , Zhonglin Shen , Hao Jiang , Minghui Yu , Min Guo , Zhuo Zhang , Pengfei Wang
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Abstract

Introducing functional elements to biomaterials is a widely recognized effective strategy to enhance their biological properties. In this study, iron (Fe) and magnesium oxide (MgO) were co-incorporated into biphasic calcium phosphate (BCP) bioceramics fabricated by vat polymerization (VPP) technique to regulate the microstructure, mechanical properties, biodegradation, biocompatibility and bioactivity. Our results showed the decrease of curing depth of BCP slurries was mainly owing to the addition of Fe. The incorporation of Fe increased the grain size, but co-incorporation of MgO decreased the grain size again. The co-incorporation of Fe and MgO increased the porosity of BCP scaffolds, and decreased their compressive strength. However, the single addition of Fe increased the compressive strength. The introducing of Fe suppressed the degradation of BCP, but Fe-Mg co-doped BCP showed faster degradation than BCP with Fe alone. However, the addition of MgO diminished the formation of bioactive apatite. In vitro, Fe-Mg co-doped BCP showed good biocompatibility, and 0.5Fe2Mg-BCP showed the best capacity on promoting osteogenic differentiation of MC3T3-E1. Fe-Mg co-doped BCP obviously regulated the RAW 264.7 polarization, inflammatory and anti-inflammatory activities which are favor of osteogenesis. This work demonstrated that the co-doping of Fe2+ and Mg2+ was favor of promoting osteogenic differentiation and Fe-Mg co-doped BCP was a promising biomaterial for bone regeneration.
Fe-Mg共掺入对体外3D打印双相磷酸钙生物陶瓷力学性能、生物降解、成骨和免疫调节的影响
在生物材料中引入功能元素是一种公认的提高生物材料生物学性能的有效方法。本研究将铁(Fe)和氧化镁(MgO)共掺入还原聚合(VPP)技术制备的双相磷酸钙(BCP)生物陶瓷中,调控其微观结构、力学性能、生物降解、生物相容性和生物活性。结果表明,铁的加入是导致BCP浆料固化深度降低的主要原因。Fe的掺入使晶粒尺寸增大,而MgO的掺入又使晶粒尺寸减小。Fe和MgO的掺入增加了BCP支架的孔隙率,降低了其抗压强度。单次添加铁可提高材料的抗压强度。Fe的引入抑制了BCP的降解,但Fe- mg共掺杂BCP的降解速度要快于单独掺杂Fe的BCP。然而,MgO的加入减少了生物活性磷灰石的形成。体外Fe-Mg共掺杂BCP表现出良好的生物相容性,其中促进MC3T3-E1成骨分化能力最好的为0.5Fe2Mg-BCP。Fe-Mg共掺杂BCP可明显调节RAW 264.7极化、炎症和抗炎活性,有利于成骨。本研究表明,Fe2+和Mg2+共掺杂有利于促进成骨分化,Fe-Mg共掺杂BCP是一种很有前景的骨再生生物材料。
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来源期刊
Ceramics International
Ceramics International 工程技术-材料科学:硅酸盐
CiteScore
9.40
自引率
15.40%
发文量
4558
审稿时长
25 days
期刊介绍: Ceramics International covers the science of advanced ceramic materials. The journal encourages contributions that demonstrate how an understanding of the basic chemical and physical phenomena may direct materials design and stimulate ideas for new or improved processing techniques, in order to obtain materials with desired structural features and properties. Ceramics International covers oxide and non-oxide ceramics, functional glasses, glass ceramics, amorphous inorganic non-metallic materials (and their combinations with metal and organic materials), in the form of particulates, dense or porous bodies, thin/thick films and laminated, graded and composite structures. Process related topics such as ceramic-ceramic joints or joining ceramics with dissimilar materials, as well as surface finishing and conditioning are also covered. Besides traditional processing techniques, manufacturing routes of interest include innovative procedures benefiting from externally applied stresses, electromagnetic fields and energetic beams, as well as top-down and self-assembly nanotechnology approaches. In addition, the journal welcomes submissions on bio-inspired and bio-enabled materials designs, experimentally validated multi scale modelling and simulation for materials design, and the use of the most advanced chemical and physical characterization techniques of structure, properties and behaviour. Technologically relevant low-dimensional systems are a particular focus of Ceramics International. These include 0, 1 and 2-D nanomaterials (also covering CNTs, graphene and related materials, and diamond-like carbons), their nanocomposites, as well as nano-hybrids and hierarchical multifunctional nanostructures that might integrate molecular, biological and electronic components.
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