Real-time super-resolution photoacoustic imaging based on speckle illumination and high-speed computed tomography

IF 3.8 2区物理与天体物理 Q1 ACOUSTICS

Ultrasonics Pub Date : 2025-05-27 DOI:10.1016/j.ultras.2025.107709

Simin Wang , Yang Liu , Chao Tao , Xiaojun Liu , Xiaoqin Qian

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引用次数: 0

Abstract

Photoacoustic imaging has demonstrated remarkable potential for providing both structural and functional information about biological tissue. However, acquiring real-time images with a resolution beyond acoustic resolution limit remains a critical challenge. In this study, we propose a speckle illumination photoacoustic computed tomography (SIPACT) system to overcome this limitation. This system combines high-repetition speckle illumination with rapid data acquisition, enabling real-time imaging. Leveraging multiple speckle-illuminated frames, the reconstruction method, based on the fast iterative shrinkage-thresholding algorithm, produces images with the resolution exceeding the acoustic limit. Numerical simulations and experiments demonstrate that the SIPACT system improves the resolution of photoacoustic image from 78 μm to 44 μm, with acquisition time that takes only 0.1 ∼ 0.2 s. This advancement enables real-time imaging and enhances image quality, which might promise valuable imaging applications in biomedical fields.

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基于散斑照明和高速计算机断层成像的实时超分辨率光声成像

光声成像在提供生物组织的结构和功能信息方面显示出显著的潜力。然而，获取超过声学分辨率限制的实时图像仍然是一个关键的挑战。在这项研究中，我们提出了一种散斑照明光声计算机断层扫描（SIPACT）系统来克服这一限制。该系统将高重复散斑照明与快速数据采集相结合，实现实时成像。该方法利用多帧散斑照明图像，基于快速迭代收缩阈值算法生成分辨率超过声学极限的图像。数值模拟和实验表明，SIPACT系统将光声图像的分辨率从78 μm提高到44 μm，采集时间仅为0.1 ~ 0.2 s。这一进步实现了实时成像，提高了图像质量，这可能会在生物医学领域带来有价值的成像应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ultrasonics 医学-核医学

CiteScore

7.60

自引率

19.00%

发文量

186

审稿时长

3.9 months

期刊介绍： Ultrasonics is the only internationally established journal which covers the entire field of ultrasound research and technology and all its many applications. Ultrasonics contains a variety of sections to keep readers fully informed and up-to-date on the whole spectrum of research and development throughout the world. Ultrasonics publishes papers of exceptional quality and of relevance to both academia and industry. Manuscripts in which ultrasonics is a central issue and not simply an incidental tool or minor issue, are welcomed. As well as top quality original research papers and review articles by world renowned experts, Ultrasonics also regularly features short communications, a calendar of forthcoming events and special issues dedicated to topical subjects.