A simple genomic score to predict progression of multiple myeloma

IF 31.7 1区生物学 Q1 GENETICS & HEREDITY

Nature genetics Pub Date : 2025-05-30 DOI:10.1038/s41588-025-02199-x

引用次数: 0

Abstract

The ‘multiple myeloma-like’ genomic score identifies somatic mutations that are more commonly found in active forms of multiple myeloma. In patients with a precursor stage of multiple myeloma, this score helps in predicting who is at a higher risk of progressing to an active form of cancer and may benefit from early therapeutic interventions.

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一个简单的基因组评分预测多发性骨髓瘤的进展

“多发性骨髓瘤样”基因组评分确定了在活动性多发性骨髓瘤中更常见的体细胞突变。在多发性骨髓瘤前期患者中，该评分有助于预测谁发展为活动性癌症的风险更高，并可能从早期治疗干预中受益。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature genetics 生物-遗传学

CiteScore

43.00

自引率

2.60%

发文量

241

审稿时长

3 months

期刊介绍： Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation. Integrative genetic topics comprise, but are not limited to: -Genes in the pathology of human disease -Molecular analysis of simple and complex genetic traits -Cancer genetics -Agricultural genomics -Developmental genetics -Regulatory variation in gene expression -Strategies and technologies for extracting function from genomic data -Pharmacological genomics -Genome evolution