Development and validation of an eating behavior patient-reported outcome measure in people living with obesity or overweight

IF 4.7 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity Pub Date : 2025-05-28 DOI:10.1002/oby.24299

Donald M. Bushnell, Shirley Fung, Meryl Brod, Carl A. Roberts, Carel W. Le Roux, Oren Steen, Kathryn J. Lucas, Anita M. Hennige, Anastasia Uster

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引用次数: 0

Abstract

Objective

The objective of this study was to develop a measure of eating behaviors in adults living with obesity or overweight.

Methods

Based on concept-elicitation (n = 53) and cognitive-debriefing (n = 15) studies, a draft eating behavior patient-reported outcome (EB PRO) measure was developed. Its psychometric properties were established using data from a 46-week clinical trial of an investigational antiobesity medication (n = 387).

Results

The final EB PRO comprised 12 items across two domains (i.e., “Desire to Eat” and “Capacity to Resist”; 6 items each) and a Total Eating Behavior score (0–48; higher scores worse). The EB PRO demonstrated good test–retest reliability (intraclass correlation coefficients > 0.7). Confirmatory factor analysis showed a comparative fit index of 0.98 with good internal consistency (Cronbach α > 0.7). The EB PRO generally exhibited moderate-to-large correlations with the Patient Global Impression of Severity questionnaire and Three-Factor Eating Questionnaire and weaker correlation with the 36-Item Short-Form Health Survey version 2 Physical Functioning scale. All EB PRO scores improved from baseline to week 46 (p < 0.0001), demonstrating sensitivity to change with therapy. Clinically meaningful thresholds were defined as eight- and four-point changes in Total Eating Behavior and domain scores, respectively.

Conclusions

The EB PRO measure is a promising tool for assessing eating behaviors in people with obesity or overweight.

Abstract Image

查看原文本刊更多论文

肥胖或超重人群饮食行为患者报告结果测量的开发和验证。

目的：本研究的目的是开发一种测量肥胖或超重成年人饮食行为的方法。方法：基于概念启发（n = 53）和认知汇报（n = 15）研究，制定了饮食行为患者报告结果（EB PRO）量表草案。其心理测量特性是通过一项为期46周的研究性抗肥胖药物临床试验（n = 387）的数据来确定的。结果：最终的EB PRO包括两个领域（即“吃的欲望”和“抵抗能力”）的12个项目；每项6项)和总饮食行为评分(0-48；分数越高越糟)。EB PRO具有良好的重测信度（类内相关系数> 0.7）。验证性因子分析显示，比较拟合指数为0.98，具有良好的内部一致性（Cronbach α > 0.7）。EB PRO与患者整体印象严重程度问卷和三因素饮食问卷普遍表现出中高相关性，与36项简短健康调查第2版身体功能量表的相关性较弱。从基线到第46周，所有EB PRO评分都有所提高(p)。结论：EB PRO测量是评估肥胖或超重人群饮食行为的一种很有前景的工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity 医学-内分泌学与代谢

CiteScore

11.70

自引率

1.40%

发文量

261

审稿时长

2-4 weeks

期刊介绍： Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.