[Risk Factor Management for Polyvascular Atherosclerosis].

Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-06-01 Epub Date: 2025-05-28 DOI:10.1055/a-2362-4893
Annika Reuser, Ulrich Laufs
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Abstract

Polyvascular atherosclerosis is characterized by atherosclerosis in several vascular territories, leading to an extremely high risk of myocardial infarction, ischemic stroke, and cardiovascular death. These patients derive a higher absolute risk reduction from preventive measures compared to individuals with monovascular atherosclerosis. The most important lifestyle factors are non-smoking and physical exercise. Pharmacological management includes lipid-lowering with an LDL-cholesterol target of <40mg/dl (1,0mmol/l) and blood-pressure control with a systolic target of 120mmHg. Diabetes type 2 in patients with polyvascular atherosclerosis should be treated with SGLT2-inhibitors and/or GLP1-receptor agonists. Patients with obesity and polyvascular disease should receive GLP1RA - regardless of the presence of diabetes. Thus, a comprehensive risk factor management in patients with polyvascular atherosclerosis is essential to improve long-term cardiovascular outcomes.

多血管粥样硬化的危险因素管理。
多血管动脉粥样硬化的特征是多个血管区域的动脉粥样硬化,导致极高的心肌梗死、缺血性卒中和心血管死亡风险。与单血管粥样硬化患者相比,这些患者从预防措施中获得了更高的绝对风险降低。最重要的生活方式因素是不吸烟和体育锻炼。药理学管理包括降脂与低密度脂蛋白胆固醇的目标
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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