Global Burden of Lower Extremity Peripheral Arterial Disease Associated with High Fasting Plasma Glucose: An Analysis of the Global Burden of Disease study 2021.
Jin Qu, Zhaoxiang Zeng, Weixue Huo, Mengwei He, Xianhao Bao, Ye Lu, Wen Tian, Rui Feng
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引用次数: 0
Abstract
Objective: High fasting plasma glucose (HFPG) is a significant risk factor for lower extremity peripheral arterial disease (PAD). No studies have investigated the detailed global burden of lower extremity PAD associated with HFPG. It is important to evaluate the current epidemiology and changing trends of HFPG related lower extremity PAD.
Methods: This study extracted two main indicators from the Global Burden of Disease database, including deaths and disability adjusted life years (DALYs) of lower extremity PAD associated with HFPG from 1990 to 2021. Subanalyses of geographical distribution, sex, age, and sociodemographic index (SDI) were performed, and estimated annual percentage changes were calculated to provide detailed insights into the disease burden.
Results: In 2021, there were 25 640 deaths and 562 161 DALYs from lower extremity PAD associated with HFPG worldwide. The global age standardised rates (ASRs) per 100 000 population of deaths and DALYs were 0.32 and 6.73, respectively. The rates of both deaths and DALYs increased with advancing age, peaking in the 95+ years age group, with rates of 31.509 and 292.935 per 100 000, respectively. The rates of deaths and DALYs were, respectively, 0.335 and 7.165 for males and 0.315 and 7.082 for females in 2021. From 1990 to 2021, the ASRs of deaths and DALYs associated with HFPG continued to increase, surpassing those associated with smoking, high body mass index, high systolic blood pressure, and kidney dysfunction.
Conclusion: Lower extremity PAD associated with HFPG remains a significant public health concern, with an uneven geographical distribution. The disease burden is higher in high SDI countries and among elderly individuals. Additionally, greater attention should be directed towards females and developing countries, as the burden of PAD associated with HFPG is gradually increasing in these groups and countries.
期刊介绍：
The European Journal of Vascular and Endovascular Surgery is aimed primarily at vascular surgeons dealing with patients with arterial, venous and lymphatic diseases. Contributions are included on the diagnosis, investigation and management of these vascular disorders. Papers that consider the technical aspects of vascular surgery are encouraged, and the journal includes invited state-of-the-art articles.
Reflecting the increasing importance of endovascular techniques in the management of vascular diseases and the value of closer collaboration between the vascular surgeon and the vascular radiologist, the journal has now extended its scope to encompass the growing number of contributions from this exciting field. Articles describing endovascular method and their critical evaluation are included, as well as reports on the emerging technology associated with this field.
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