Relationship of Deep Capillary Plexus Nonperfusion to Visual Acuity and Low Light Vision in Diabetic Retinopathy through OCTA Analysis.

IF 2.3 2区医学 Q2 OPHTHALMOLOGY

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-05-27 DOI:10.1097/IAE.0000000000004517

Daniela Castellanos-Canales, Brandon V Duffy, Nicole L Decker, Taffeta Chingning Yamaguchi, Elizabeth Pearce, Amani A Fawzi

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引用次数: 0

Abstract

Purpose: Considering its proximity to photoreceptors, we evaluated the relationship of nonperfusion at the deep capillary plexus (DCP) to visual acuity (VA) in eyes with diabetic retinopathy (DR).

Methods: Our study included 313 eyes with no retinopathy (DMnoDR) to proliferative DR (PDR). Optical coherence tomography angiography (OCTA) scans of the DCP and superficial capillary plexus (SCP) were averaged to measure vessel density (VD), vessel length density (VLD), and geometric perfusion deficit (GPD). Best corrected VA (BCVA) and low-luminance VA (LLVA) were measured per the Early Treatment Diabetic Retinopathy Study (ETDRS) protocol.

Results: We found a significant correlation between BCVA and DCP-VD, DCP-VLD and DCP-GPD (r=.270, r= .352 and r= -.362, p<0.001, respectively). These relationships were also significant for LLVA: DCP-VD, DCP-VLD and DCP-GPD (r=.335, r= .421 and r= -.396, p<0.001, respectively).At the SCP level we found relationships between VD and VLD metrics with BCVA (r=.303 and r=.300, p<0.001, respectively) as well as with LLVA (r=.315 and r=.314, p<0.001, respectively). GPD exhibited a negative correlation with BCVA and LLVA (r=-.265 and r= -.279, p<0.001).

Conclusion: Nonperfusion in the DCP and SCP correlate to vision loss, suggesting that capillary loss affects both BCVA and LLVA. Interestingly, the ischemic changes in the DCP have a stronger relationship to vision.

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糖尿病视网膜病变深毛细血管丛不灌注与视力及弱光视力的关系。

目的：探讨糖尿病视网膜病变（DR）眼深部毛细血管丛（DCP）非灌注与视力（VA）的关系。方法：本研究纳入313只无视网膜病变（DMnoDR）至增殖性视网膜病变（PDR）的眼。取DCP和浅毛细血管丛（SCP）光学相干断层扫描（OCTA）的平均值，测量血管密度（VD）、血管长度密度（VLD）和几何灌注缺陷（GPD）。根据早期治疗糖尿病视网膜病变研究（ETDRS）方案测量最佳校正VA （BCVA）和低亮度VA （LLVA）。结果：我们发现BCVA与DCP-VD、DCP-VLD、DCP-GPD有显著相关性(r=。270 r=。352 r= -。362， p结论：DCP和SCP未灌注与视力丧失相关，提示毛细血管丧失对BCVA和LLVA均有影响。有趣的是，DCP的缺血性变化与视力有更强的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Retina-The Journal of Retinal and Vitreous Diseases 医学-眼科学

CiteScore

5.70

自引率

9.10%

发文量

554

审稿时长

3-6 weeks

期刊介绍： RETINA® focuses exclusively on the growing specialty of vitreoretinal disorders. The Journal provides current information on diagnostic and therapeutic techniques. Its highly specialized and informative, peer-reviewed articles are easily applicable to clinical practice. In addition to regular reports from clinical and basic science investigators, RETINA® publishes special features including periodic review articles on pertinent topics, special articles dealing with surgical and other therapeutic techniques, and abstract cards. Issues are abundantly illustrated in vivid full color. Published 12 times per year, RETINA® is truly a “must have” publication for anyone connected to this field.