Effectivity of Topical Quinolones and Metronidazole on Cancer Ulcers in Patients with Locally Advanced Breast Cancer: A Randomized Controlled Trial.

Q2 Medicine

Asian Pacific Journal of Cancer Prevention Pub Date : 2025-05-01 DOI:10.31557/APJCP.2025.26.5.1607

Selamat Budijitno, Puguh Sihwidiyono, Luqman Alwi, Dwi Pudjonarko, Tri Nur Kristina, Meira Dwi Kusuma Astuti, Arrizki Azka Pratama, Sistiya Pradana Putra

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引用次数: 0

Abstract

Introduction: Malignant Fungating Wound (MFW) has a significant role in increasing quality of life. The secondary infection could cause as well as Hemorrhage, Odor, Pain, Exudate & Superficial infections (HOPES) and reduced activity. Worseness of MFW could be caused by a combination of aerobic and anaerobic bacterial infections. This study aimed to prove the effectiveness of the topical antibiotic solution toward wound repairment secondary to MFW. Methods: This study was a pre and post-test randomized controlled trial in which inclusion and exclusion criteria were predefined. Patients who suffered locally advanced breast cancer were given chemotherapy and then randomized into the treatment group of MFW management treated with Ciprofloxacin and Metronidazole solution, and the non-treatment group treated with 0.9% NaCl. The dependent variable was the number of Colony Forming Unit (CFU) and the degree of fibrosis. Mann Whitney-U and Kendall's tau-b test was carried out to examine the difference and correlation test. Statistical significance was defined as p <0.05.

Result: The study involved 40 patients who were randomized into the treatment group dan the non-treatment group. Paired T-tests of the CFU in the non-treatment group and the treatment group are significant (p<0.001). The Mann Whitney-U test in delta CFU in both groups is significant (p<0.001). Mann Whitney-U test in the degree of fibrosis in both groups is significant (p=0.046). Kendall's tau-b correlation test shows a significant negative correlation between the CFU and the degree of fibrosis (p=0.027, r=-0.36).

Conclusion: The treatment of MFW in locally advanced breast cancer treated with metronidazole and ciprofloxacin solution gives a better rate of improvement in terms of reducing the number of CFU and increasing the degree of fibrosis. This study proves that there is a significant negative correlation between a decrease in CFU and the degree of fibrosis in the treatment group.

查看原文本刊更多论文

局部喹诺酮类药物和甲硝唑治疗局部晚期乳腺癌患者癌症溃疡的疗效：一项随机对照试验。

恶性真菌性伤口（MFW）在提高生活质量方面具有重要作用。继发性感染可引起出血，气味，疼痛，渗出液和浅表感染（希望）和活动减少。MFW的恶化可能是由好氧和厌氧细菌感染共同引起的。本研究旨在证明外用抗生素溶液对MFW继发性伤口修复的有效性。方法：本研究采用试验前和试验后随机对照试验，预先确定纳入标准和排除标准。局部晚期乳腺癌患者给予化疗后，随机分为MFW治疗组以环丙沙星+甲硝唑溶液治疗，非治疗组以0.9% NaCl治疗。因变量为菌落形成单位（Colony Forming Unit， CFU）数和纤维化程度。采用Mann Whitney-U和Kendall的tau-b检验进行差异检验和相关检验。结果：本研究共纳入40例患者，随机分为治疗组和非治疗组。非治疗组和治疗组CFU配对t检验均有显著性差异(p结论：甲硝唑和环丙沙星溶液治疗局部晚期乳腺癌MFW在减少CFU数量和增加纤维化程度方面有更好的改善率。本研究证明治疗组CFU下降与纤维化程度呈显著负相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Pacific Journal of Cancer Prevention 医学-肿瘤学

CiteScore

2.80

自引率

0.00%

发文量

779

审稿时长

3 months

期刊介绍： Cancer is a very complex disease. While many aspects of carcinoge-nesis and oncogenesis are known, cancer control and prevention at the community level is however still in its infancy. Much more work needs to be done and many more steps need to be taken before effective strategies are developed. The multidisciplinary approaches and efforts to understand and control cancer in an effective and efficient manner, require highly trained scientists in all branches of the cancer sciences, from cellular and molecular aspects to patient care and palliation. The Asia Pacific Organization for Cancer Prevention (APOCP) and its official publication, the Asia Pacific Journal of Cancer Prevention (APJCP), have served the community of cancer scientists very well and intends to continue to serve in this capacity to the best of its abilities. One of the objectives of the APOCP is to provide all relevant and current scientific information on the whole spectrum of cancer sciences. They aim to do this by providing a forum for communication and propagation of original and innovative research findings that have relevance to understanding the etiology, progression, treatment, and survival of patients, through their journal. The APJCP with its distinguished, diverse, and Asia-wide team of editors, reviewers, and readers, ensure the highest standards of research communication within the cancer sciences community across Asia as well as globally. The APJCP publishes original research results under the following categories: -Epidemiology, detection and screening. -Cellular research and bio-markers. -Identification of bio-targets and agents with novel mechanisms of action. -Optimal clinical use of existing anti-cancer agents, including combination therapies. -Radiation and surgery. -Palliative care. -Patient adherence, quality of life, satisfaction. -Health economic evaluations.