Alzheimer's and dementia: Diagnosis, assessment, and disease monitoring global, regional, and national burden of Alzheimer's disease and other dementias (ADODs) and their risk factors, 1990-2021: A systematic analysis for the Global Burden of Disease study 2021.
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引用次数: 0
Abstract
Introduction: Aging populations globally lead to growing challenges in Alzheimer's disease and other dementias (ADODs). Tracking ADODs aids health strategies. To describe global, regional, and national incidence, prevalence, death, and disability-adjusted life years (DALYs) of ADODs in 2021, and analyze changes from 1990 to 2021.
Methods: We analyzed ADODs using the 2021 Global Burden of Disease database, calculating estimated annual percentage change (EAPC), applying Joinpoint regression, and assessing risk factors.
Results: Between 1990 and 2021, ADOD incidence, prevalence, deaths, and DALYs increased significantly. DALYs grew 295.45% and fatalities grew 167.72%. Age-standardized rates (ASRs) rose for both genders, with women generally higher but men showing steeper increases. ASRs correlated positively with Sociodemographic Index. Risk factor contribution to DALYs and death rose by 4.1%. In 2021, metabolic factors and high fasting plasma glucose most influenced ADODs.
Discussion: The global ADOD burden has risen since 1990. Early screening, especially for elderly women, is crucial. Policymakers must act to reverse this trend.
Highlights: Based on Global Burden of Disease data 1990-2021, the incidence, prevalence, mortality, and disability-adjusted life years due to Alzheimer's and dementia are depicted globally, regionally, and nationally.The effects of gender and age were explored.The contribution of different risk factors to the disease was studied.
期刊介绍：
Alzheimer''s & Dementia: Diagnosis, Assessment & Disease Monitoring (DADM) is an open access, peer-reviewed, journal from the Alzheimer''s Association® that will publish new research that reports the discovery, development and validation of instruments, technologies, algorithms, and innovative processes. Papers will cover a range of topics interested in the early and accurate detection of individuals with memory complaints and/or among asymptomatic individuals at elevated risk for various forms of memory disorders. The expectation for published papers will be to translate fundamental knowledge about the neurobiology of the disease into practical reports that describe both the conceptual and methodological aspects of the submitted scientific inquiry. Published topics will explore the development of biomarkers, surrogate markers, and conceptual/methodological challenges. Publication priority will be given to papers that 1) describe putative surrogate markers that accurately track disease progression, 2) biomarkers that fulfill international regulatory requirements, 3) reports from large, well-characterized population-based cohorts that comprise the heterogeneity and diversity of asymptomatic individuals and 4) algorithmic development that considers multi-marker arrays (e.g., integrated-omics, genetics, biofluids, imaging, etc.) and advanced computational analytics and technologies.
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