{"title":"Transcriptome analysis of testes gene expression to explore genetic diversity of Mangalica and Camborough boars.","authors":"Keigo Yamane, Sangwoo Kim, Akari Koide, Erina Yoneda, Mitsunori Kayano, Yuki Muranishi","doi":"10.1038/s41597-025-05196-1","DOIUrl":null,"url":null,"abstract":"<p><p>The testis, an important reproductive organ, is involved in spermatogenesis and steroid hormone secretion and has been the subject of a wide variety of studies. Pigs are often used as model animals for studies on human physiology and disease, and studies on the testicular development of pigs could shed light on human reproduction. Mangalica, an indigenous Hungarian pig breed, has reproductive traits that are different from those of commercial pig breeds. This specificity could reveal important differences in the cascades and reproductive genes between humans and other animals. In this study, we conducted RNA-sequencing analysis of the testes of 14 days old Mangalica and Camborough boars. We also performed clustering and pathway analysis of differentially expressed genes. These datasets and analyses are expected to provide important gene sets for pig testis development that can be applied in future studies on human reproductive mechanisms.</p>","PeriodicalId":21597,"journal":{"name":"Scientific Data","volume":"12 1","pages":"888"},"PeriodicalIF":5.8000,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119833/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Scientific Data","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.1038/s41597-025-05196-1","RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
The testis, an important reproductive organ, is involved in spermatogenesis and steroid hormone secretion and has been the subject of a wide variety of studies. Pigs are often used as model animals for studies on human physiology and disease, and studies on the testicular development of pigs could shed light on human reproduction. Mangalica, an indigenous Hungarian pig breed, has reproductive traits that are different from those of commercial pig breeds. This specificity could reveal important differences in the cascades and reproductive genes between humans and other animals. In this study, we conducted RNA-sequencing analysis of the testes of 14 days old Mangalica and Camborough boars. We also performed clustering and pathway analysis of differentially expressed genes. These datasets and analyses are expected to provide important gene sets for pig testis development that can be applied in future studies on human reproductive mechanisms.
期刊介绍：
Scientific Data is an open-access journal focused on data, publishing descriptions of research datasets and articles on data sharing across natural sciences, medicine, engineering, and social sciences. Its goal is to enhance the sharing and reuse of scientific data, encourage broader data sharing, and acknowledge those who share their data.
The journal primarily publishes Data Descriptors, which offer detailed descriptions of research datasets, including data collection methods and technical analyses validating data quality. These descriptors aim to facilitate data reuse rather than testing hypotheses or presenting new interpretations, methods, or in-depth analyses.
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