Bruch's membrane opening (BMO) based peripapillary OCT-A analysis.

IF 2 4区医学 Q2 OPHTHALMOLOGY

Ophthalmic Research Pub Date : 2025-05-28 DOI:10.1159/000545878

Sebastian Fassihi Dehkordi, Julia Schottenhamml, Meike Müller, Sami Hosari, Robert Lämmer, Andreas Maier, Bettina Hohberger, Christian Mardin

{"title":"Bruch's membrane opening (BMO) based peripapillary OCT-A analysis.","authors":"Sebastian Fassihi Dehkordi, Julia Schottenhamml, Meike Müller, Sami Hosari, Robert Lämmer, Andreas Maier, Bettina Hohberger, Christian Mardin","doi":"10.1159/000545878","DOIUrl":null,"url":null,"abstract":"Purpose: Peripapillary OCT-A scans are a challenge for vessel density (VD) analysis, being dependent on demarcation of the optic disc. Longitudinal VD analysis requires that each pixel of the OCT-A scan must be at the exact same location during follow-up scans in order to see inter-visit differences. The aim of the present study was to investigate reliability of BMO-based peripapillary OCT-A analysis with and without the implementation of the Anatomical Positioning System (APS) compared to manual analysis.Methods: Thirty-seven eyes were measured twice by OCT-A (Heidelberg OCT II Spectralis) and analysed by the Erlangen Angio-Tool (EA-Tool) with an APS- and BMO-based analysis of the macula and peripapillary region. APS allows alignment of OCT-A scans according to each individual FoBMOC (Fovea-to-Bruch's Membrane Opening-Center). Peripapillary OCT-A scans were analysed: (I) manually (by the shortest distance of the vertical or horizontal diameter of the optic disc), (II) BMO-based, and (III) BMO-based with APS information. Coefficients of variation (CV) were calculated.Results: Peripapillary mean VD was 42.52±4 and 41.69±4 (manually), 50.29±4 and 48.8±4 (BMO-based), and 44.73±3 and 44.39±4 (BMO-based and APSified) for 1st and 2nd scan, respectively. Peripapillary mean VD yielded a significant difference between the 1st and 2nd scan for manual (p=0.04), but not for BMO-based (p>0.05) and BMO-based and APSified analysis (p>0.05). CV were 10.0 (manually), 8.0 (BMO-based), and 8.0 (BMO-based and APSified).Conclusion: The integration of BMO and APS information into the EA-Tool allows a BMO-based peripapillary VD analysis for long-term OCT-A analysis.","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"1-15"},"PeriodicalIF":2.0000,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ophthalmic Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000545878","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: Peripapillary OCT-A scans are a challenge for vessel density (VD) analysis, being dependent on demarcation of the optic disc. Longitudinal VD analysis requires that each pixel of the OCT-A scan must be at the exact same location during follow-up scans in order to see inter-visit differences. The aim of the present study was to investigate reliability of BMO-based peripapillary OCT-A analysis with and without the implementation of the Anatomical Positioning System (APS) compared to manual analysis.

Methods: Thirty-seven eyes were measured twice by OCT-A (Heidelberg OCT II Spectralis) and analysed by the Erlangen Angio-Tool (EA-Tool) with an APS- and BMO-based analysis of the macula and peripapillary region. APS allows alignment of OCT-A scans according to each individual FoBMOC (Fovea-to-Bruch's Membrane Opening-Center). Peripapillary OCT-A scans were analysed: (I) manually (by the shortest distance of the vertical or horizontal diameter of the optic disc), (II) BMO-based, and (III) BMO-based with APS information. Coefficients of variation (CV) were calculated.

Results: Peripapillary mean VD was 42.52±4 and 41.69±4 (manually), 50.29±4 and 48.8±4 (BMO-based), and 44.73±3 and 44.39±4 (BMO-based and APSified) for 1st and 2nd scan, respectively. Peripapillary mean VD yielded a significant difference between the 1st and 2nd scan for manual (p=0.04), but not for BMO-based (p>0.05) and BMO-based and APSified analysis (p>0.05). CV were 10.0 (manually), 8.0 (BMO-based), and 8.0 (BMO-based and APSified).

Conclusion: The integration of BMO and APS information into the EA-Tool allows a BMO-based peripapillary VD analysis for long-term OCT-A analysis.

查看原文本刊更多论文

基于Bruch膜开口（BMO）的乳头周围OCT-A分析。

目的：乳头周围OCT-A扫描是血管密度（VD）分析的挑战，依赖于视盘的划分。纵向VD分析要求OCT-A扫描的每个像素在后续扫描中必须处于完全相同的位置，以便观察每次扫描之间的差异。本研究的目的是研究基于bmo的乳头周围OCT-A分析的可靠性，与手工分析相比，有无实施解剖定位系统（APS）。方法：用OCT- a （Heidelberg OCT II Spectralis）对37只眼进行2次测量，并用Erlangen血管造影工具（EA-Tool）对黄斑和乳头周围区域进行APS和bmo分析。APS允许OCT-A扫描根据每个单独的FoBMOC（中央凹-布鲁氏膜开口中心）对齐。对乳头周围OCT-A扫描进行分析：(I)手动（视盘垂直或水平直径的最短距离），（II）基于bmo，（III）基于APS信息的bmo。计算变异系数（CV）。结果：第一次和第二次扫描乳头周围平均VD分别为42.52±4和41.69±4（手动），50.29±4和48.8±4 (BMO-based)， 44.73±3和44.39±4 （BMO-based和APSified）。第一次和第二次手工扫描的乳头周围平均VD有显著性差异（p=0.04），但基于bmo的分析（p>0.05）和基于bmo和APSified分析（p>0.05）没有显著性差异。CV分别为10.0（手动）、8.0（基于bmo）和8.0（基于bmo和APSified）。结论：将BMO和APS信息整合到EA-Tool中，可以进行基于BMO的乳头周围VD分析，用于长期OCT-A分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Ophthalmic Research 医学-眼科学

CiteScore

3.80

自引率

4.80%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Ophthalmic Research'' features original papers and reviews reporting on translational and clinical studies. Authors from throughout the world cover research topics on every field in connection with physical, physiologic, pharmacological, biochemical and molecular biological aspects of ophthalmology. This journal also aims to provide a record of international clinical research for both researchers and clinicians in ophthalmology. Finally, the transfer of information from fundamental research to clinical research and clinical practice is particularly welcome.